Maternal levels of serum-soluble CD8 and IL-2R are not significantly elevated in idiopathic preterm labour
| Autor: | Judith N. Bulmer, M.J. Divers, David Miller, Andy Vail, Richard J. Lilford |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Interleukin 2
medicine.medical_specialty medicine.medical_treatment T cell CD8 Antigens Inflammation Obstetric Labor Premature Pregnancy Internal medicine medicine Humans Receptor Analysis of Variance business.industry Obstetrics and Gynecology Receptors Interleukin-2 medicine.disease Endocrinology Cytokine medicine.anatomical_structure Reproductive Medicine Solubility Female Analysis of variance medicine.symptom business CD8 medicine.drug |
| Zdroj: | European journal of obstetrics, gynecology, and reproductive biology. 62(2) |
| ISSN: | 0301-2115 |
| Popis: | Objective: To search for evidence of immune activation in idiopathic preterm term labour by measuring the soluble markers of T cell activation, CD8 (sCD8) and interleukin-2 receptor (sIL2R). Design: Serum sCD8 and sIL-2R were measured by commercial ELISA in subjects undergoing idiopathic preterm labour (PTL; n = 15) and normal term labour (TL; n = 17). Two gestationally equivalent non-labouring groups were also included representing preterm (PTC; n = 10) and term (TC; n = 10) controls. Possible delayed responses in soluble activation markers were monitored in blood samples taken 48 h after delivery in both labouring groups (PTLp; n = 9: TLp; n = 9). Results: (1) Excluding the 48 h postpartum samples, no statistically significant differences were revealed following a Kruskall-Wallis analysis of variance (ANOVA) for levels of sIL-2R (P = 0.093) and sCD8 (P = 0.098). Including the postpartum samples, however, gave statistically significant differences for each (sIL-2R: P = 0.033; sCD8: P = 0.006). (2) No statistically significant difference was revealed by direct comparison of the two labouring groups alone (Wilcoxon-Mann-Whitney test: P > 0.05). (3) Significantly lower levels of sCD8 were found in the PTL subgroup which had histological evidence of inflammation (Wilcoxon-Mann-Whitney: P = 0.003). Conclusions: Statistical analysis of our data suggests that idiopathic preterm labour is not commonly associated with significant elevations in circulating sCD8 or sIL-2R levels compared with normal term labour. Where significant changes in the levels of these markers do arise, our evidence points to a delayed effect of labour per se rather than infection as the most probable cause. |
| Databáze: | OpenAIRE |
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