EBV LMP-1 negatively regulates expression and pro-apoptotic activity of Par-4 in nasopharyngeal carcinoma cells
| Autor: | Lee-Ping Hsu, Chung-Hsing Chang, Wen-Ling Shih, Peir-Rong Chen, Jeng-Woei Lee, Po-Fan Liu |
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| Rok vydání: | 2009 |
| Předmět: |
Cancer Research
endocrine system diseases viruses Nasopharyngeal neoplasm Apoptosis Viral Matrix Proteins Phosphatidylinositol 3-Kinases Cell Line Tumor hemic and lymphatic diseases otorhinolaryngologic diseases medicine Humans PI3K/AKT/mTOR pathway Regulation of gene expression Chemistry Activator (genetics) Nasopharyngeal Neoplasms medicine.disease Cyclic AMP-Dependent Protein Kinases Cell biology Gene Expression Regulation Neoplastic stomatognathic diseases Proto-Oncogene Proteins c-bcl-2 Oncology Nasopharyngeal carcinoma Cell culture Cancer research Signal transduction Apoptosis Regulatory Proteins Proto-Oncogene Proteins c-akt Signal Transduction |
| Zdroj: | Cancer Letters. 279:193-201 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/j.canlet.2009.01.037 |
| Popis: | Latent membrane protein-1 (LMP-1) of the Epstein-Barr virus (EBV) is closely associated with nasopharyngeal carcinoma (NPC), and in this study we sought to determine whether the pro-apoptotic activity of prostate apoptosis response-4 (Par-4) is modulated by LMP-1 in NPC cells. We found that LMP-1 diminished the pro-apoptotic activity of Par-4 and negatively regulated Par-4 protein by de novo synthesis; moreover, although LMP-1 accelerated a Par-4 activator, PKA, we demonstrated that LMP-1 also activated the PI3 K/Akt pathway and increased Bcl-2 expression to suppress the activity of Par-4. Consequently, our results revealed a novel negative action of LMP-1 on the pro-apoptosis protein Par-4 by the coordination of multiple signaling pathways. |
| Databáze: | OpenAIRE |
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