Nitrate tolerance and aging in isolated rat aorta
| Autor: | Jeanine Fontaine, Dmitri Brékine, Philippe Unger, Guy Berkenboom |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Aging Molsidomine Metabolite medicine.medical_treatment Muscle Relaxation Vasodilator Agents Aorta Thoracic In Vitro Techniques Toxicology Muscle Smooth Vascular chemistry.chemical_compound Nitroglycerin Phenylephrine Nitrate Internal medicine medicine.artery medicine Animals Rats Wistar Active metabolite Desensitization (medicine) Pharmacology Aorta Dose-Response Relationship Drug Drug Tolerance Pollution Rats Endocrinology chemistry Anesthesia Circulatory system cardiovascular system medicine.drug Muscle Contraction |
| Zdroj: | European journal of pharmacology. 248(2) |
| ISSN: | 0014-2999 |
| Popis: | The purpose of this study was to determine whether there are age-related changes in the extent of in vitro-induced nitrate tolerance. Nitroglycerin pre-exposure (10 μM for 30 min) provoked a significant shift to the right of the dose-response curve to nitroglycerin in aortae isolated from rats of 8 weeks, 12 and 18 months. However, this shift to the right was significantly larger at 18 months, both when KCl or phenylephrine were used as contractile agents. On the contrary, nitroglycerin pre-exposure did not significantly alter the dose-dependent relaxation to Sin-1 (3-morpholinosydnonimine, the active metabolite of molsidomine) at 8 weeks, 12 and 18 months. These data indicate that the extent of the in vitro-induced nitrate tolerance is larger when aortae are isolated from senescent rats. This increase in tolerance does not appear to involve desensitization of guanylate cyclase. |
| Databáze: | OpenAIRE |
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