Influence of remote ischemic conditioning and tramadol hydrochloride on oxidative stress in kidney ischemia/reperfusion injury in rats
| Autor: | Lainy Carollyne da Costa Cavalcante, Rubens Fernando Gonçalves Ribeiro Júnior, Higor Yuri Bezerra Henriques, Fernando Mateus Viégas Brandão, Andrew Moraes Monteiro, Eduardo Henrique Herbster Gouveia, Rita de Cássia Silva de Oliveira, Leonam Oliver Durval Oliveira, Marcus Vinicius Henriques Brito |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Time Factors RD1-811 medicine.medical_treatment Ischemia 030204 cardiovascular system & hematology Protective Agents Kidney 03 medical and health sciences Random Allocation 0302 clinical medicine Malondialdehyde Medicine Animals Rats Wistar Ischemic Preconditioning Tramadol Renal ischemia business.industry Kidney metabolism Reproducibility of Results Rats medicine.disease Combined Modality Therapy Nephrectomy Oxidative Stress medicine.anatomical_structure Treatment Outcome 030220 oncology & carcinogenesis Anesthesia Reperfusion Injury Reperfusion Tramadol Hydrochloride Surgery business Reperfusion injury medicine.drug |
| Zdroj: | Acta Cirúrgica Brasileira v.32 n.3 2017 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC Acta Cirurgica Brasileira, Volume: 32, Issue: 3, Pages: 229-235, Published: MAR 2017 Acta Cirurgica Brasileira, Vol 32, Iss 3, Pp 229-235 (2017) |
| Popis: | Purpose: To evaluate the effects of tramadol hydrochloride associated to remote ischemic perconditioning on oxidative stress. Methods: Twenty five male rats (Wistar) underwent right nephrectomy and were distributed into five groups: Sham group (S); Ischemia/Reperfusion group (I/R) with 30 minutes of renal ischemia; Remote ischemic perconditioning group (Per) with three cycles of 10 minutes of I/R performed during kidney ischemia; Tramadol group (T) treated with tramadol hydrochloride (40mg/kg); remote ischemic perconditioning + Tramadol group (Per+T) with both treatments. Oxidative stress was assessed after 24 hours of reperfusion. Results: Statistical differences were observed in MDA levels between I/R group with all groups (p |
| Databáze: | OpenAIRE |
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