Integrated Analytical Tools for Accessing Acridones and Unrelated Phenylacrylamides from Swinglea glutinosa
| Autor: | Thiago André Moura Veiga, Ana Calheiros de Carvalho, Alany Ingrid Ribeiro, Lívia Soman de Medeiros, Luiza De Camillis Rodrigues, Maria Fátima das Graças Fernandes da Silva |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Magnetic Resonance Spectroscopy
Secondary Metabolism Pharmaceutical Science Target analysis 01 natural sciences Article Styrenes Analytical Chemistry Lansiumamide B lcsh:QD241-441 03 medical and health sciences chemistry.chemical_compound acridones lcsh:Organic chemistry Drug Discovery Metabolomics Physical and Theoretical Chemistry Rutaceae Chromatography High Pressure Liquid 030304 developmental biology Acrylamides 0303 health sciences Natural product Chromatography Molecular Structure 010405 organic chemistry Swinglea glutinosa Organic Chemistry Visual identification dereplication 0104 chemical sciences chemistry Cinnamates Chemistry (miscellaneous) phenylacrylamides Molecular Medicine |
| Zdroj: | Molecules Volume 25 Issue 1 Molecules, Vol 25, Iss 1, p 153 (2019) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules25010153 |
| Popis: | In natural product studies, the purification of metabolites is an important challenge. To accelerate this step, alternatives such as integrated analytical tools should be employed. Based on this, the chemical study of Swinglea glutinosa (Rutaceae) was performed using two rapid dereplication strategies: Target Analysis (Bruker Daltonics® Bremen, Germany) MS data analysis combined with MS/MS data obtained from the GNPS platform. Through UHPLC-HRMS data, the first approach allowed, from crude fractions, a quick and visual identification of compounds already reported in the Swinglea genus. Aside from this, by grouping compounds according to their fragmentation patterns, the second approach enabled the detection of eight molecular families, which presented matches for acridonic alkaloids, phenylacrylamides, and flavonoids. Unrelated compounds for S. glutinosa have been isolated and characterized by NMR experiments, Lansamide I, Lansiumamide B, Lansiumamide C, and N-(2-phenylethyl)cinnamamide. |
| Databáze: | OpenAIRE |
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