I Keep a Close Watch on This Heart of Mine: Increased Interoception in Insomnia

Autor: Michele A Colombo, Bart H W Te Lindert, Yishul Wei, Wisse P. van der Meijden, Ysbrand D. van der Werf, Diederick Stoffers, Germán Gómez-Herrero, Eus J.W. Van Someren, Jennifer R Ramautar
Přispěvatelé: Integrative Neurophysiology, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Netherlands Institute for Neuroscience (NIN), Anatomy and neurosciences, Psychiatry
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Male
medicine.medical_treatment
Electroencephalography
Audiology
Developmental psychology
Interoception
Electrocardiography
0302 clinical medicine
Insomnia disorder
Sleep Initiation and Maintenance Disorders
Salience network
Resting state
Evoked Potentials
Cerebral Cortex
Brain Mapping
medicine.diagnostic_test
05 social sciences
Heart
Awareness
Middle Aged
High-density EEG
medicine.anatomical_structure
Wakefulness
Female
Psychology
Arousal
Adult
medicine.medical_specialty
Event-related potential
Insomnia
Sensory processing
Hyperarousal
Sensory system
050105 experimental psychology
03 medical and health sciences
Young Adult
SDG 3 - Good Health and Well-being
Physiology (medical)
medicine
Humans
0501 psychology and cognitive sciences
Heartbeat-evoked potential
Aged
Neurocirculatory Asthenia
Resting state fMRI
Scalp
Neurology (clinical)
030217 neurology & neurosurgery
Zdroj: SLEEP
Wei, Y, Ramautar, J R, Colombo, M A, Stoffers, D, Gómez-Herrero, G, Van Der Meijden, W P, Te Lindert, B H W, Van Der Werf, Y D & Van Someren, E J W 2016, ' I keep a close watch on this heart of mine : Increased interoception in Insomnia ', Sleep, vol. 39, no. 12, pp. 2113-2124 . https://doi.org/10.5665/sleep.6308
Sleep, 39(12), 2113-2124. American Academy of Sleep Medicine
Wei, Y, Ramautar, J R, Colombo, M A, Stoffers, D, Gomez-Herrero, G, van der Meijden, W P, te Lindert, B H W, van der Werf, Y D & van Someren, E J W 2016, ' I Keep a Close Watch on This Heart of Mine: Increased Interoception in Insomnia ', Sleep, vol. 39, no. 12, pp. 2113-2124 . https://doi.org/10.5665/sleep.6308
Sleep, 39, 2113-2124. American Academy of Sleep Medicine
ISSN: 0161-8105
Popis: Study Objectives:Whereas both insomnia and altered interoception are core symptoms in affective disorders, their neural mechanisms remain insufficiently understood and have not previously been linked. Insomnia Disorder (ID) is characterized by sensory hypersensitivity during wakefulness and sleep. Previous studies on sensory processing in ID addressed external stimuli only, but not interoception. Interoceptive sensitivity can be studied quantitatively by measuring the cerebral cortical response to one's heartbeat (heartbeat-evoked potential, HEP). We here investigated whether insomnia is associated with increased interoceptive sensitivity as indexed by the HEP amplitude.Methods:Sixty-four participants aged 21–70 years were recruited through www.sleepregistry.nl including 32 people suffering from ID and 32 age- and sex-matched controls without sleep complaints. HEPs were obtained from resting-state high-density electroencephalography (HD-EEG) recorded during evening wakeful rest in eyes-open (EO) and eyes-closed (EC) conditions of 5-minute duration each. Significance of group differences in HEP amplitude and their topographical distribution over the scalp were assessed by means of cluster-based permutation tests.Results:In particular during EC, and to a lesser extent during EO, people with ID had a larger amplitude late HEP component than controls at frontal electrodes 376–500 ms after the R-wave peak. Source localization suggested increased neural activity time-locked to heartbeats in people with ID mainly in anterior cingulate/medial frontal cortices.Conclusions:People with insomnia show insufficient adaptation of their brain responses to the ever-present heartbeats. Abnormalities in the neural circuits involved in interoceptive awareness including the salience network may be of key importance to the pathophysiology of insomnia.
Databáze: OpenAIRE
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