Gene polymorphisms and oral cancer risk in tobacco habitués
| Autor: | Shaleen Multani, Dhananjaya Saranath, Sultan Pradhan |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Risk 0301 basic medicine medicine.medical_specialty Tobacco Smokeless Genotype India Single-nucleotide polymorphism Biology Bioinformatics Polymorphism Single Nucleotide Gastroenterology Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine Odds Ratio medicine Humans SNP Allele Alleles Aged Neoplasm Staging Aged 80 and over Mouth neoplasm Case-control study Cancer General Medicine Odds ratio Middle Aged medicine.disease 030104 developmental biology Case-Control Studies 030220 oncology & carcinogenesis Female Mouth Neoplasms Disease Susceptibility Neoplasm Grading |
| Zdroj: | Tumor Biology. 37:6169-6176 |
| ISSN: | 1423-0380 1010-4283 |
| DOI: | 10.1007/s13277-015-4448-1 |
| Popis: | Oral cancer incidence of 77,003 poses a major health concern in India, with 5-10 % tobacco habitues developing oral cancer. The current study examined the role of specific genomic variants in oral cancer. We examined five genomic variants represented as single nucleotide polymorphisms (SNPs) in genes associated with cell proliferation and cellular invasion. The SNPs rs2124437 (RASGRP3), rs1335022 (GRIK2), rs4512367 (PREX2), rs4748011 (CCDC3), and rs1435218 (LNX1) were analyzed in 500 histopathologically confirmed oral cancers and 500 healthy controls with a minimum of 10 years of tobacco usage. Allelic discrimination real-time PCR SYBR Green assay was used. The genotypic and allelic frequencies between cases and controls were analyzed using SPSS software (version 19) and odds ratio (OR) using Hutchon.net, indicating increased risk to oral cancers. A significant association of the SNPs in oral cancer was observed in RASGRP3 AA (rs2124437) (p |
| Databáze: | OpenAIRE |
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