PD-1 and PD-L1 regulate cellular immunity in canine visceral leishmaniasis
| Autor: | Vanessa Marin Chiku, Paulo Sergio Patto dos Santos, Aline Aparecida Correa Leal, Gisele Fabrino Machado, Flávia de Rezende Eugênio, Breno Fernando de Almeida, Gabriela Luvizotto Venturin, Kathlenn Liezbeth Oliveira Silva, Valéria Marçal Felix de Lima |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp) |
| Rok vydání: | 2018 |
| Předmět: |
Male
Cellular immunity medicine.medical_treatment Programmed Cell Death 1 Receptor Gene Expression B7-H1 Antigen Parasite Load Canine 0403 veterinary science 0302 clinical medicine PD-1 Leukocytes Immunology and Allergy Dog Diseases Lymphocytes Visceral leishmaniasis Immunity Cellular biology 04 agricultural and veterinary sciences General Medicine Immunohistochemistry Lymphoproliferation Infectious Diseases medicine.anatomical_structure Cytokine Cytokines Leishmaniasis Visceral Female Antibody 040301 veterinary sciences 030231 tropical medicine Immunology Spleen Microbiology Immunophenotyping 03 medical and health sciences Immune system Dogs PD-L1 medicine Animals General Veterinary Macrophages Nitric oxide medicine.disease biology.protein Lymphoproliferative response |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 1878-1667 |
| Popis: | Made available in DSpace on 2019-10-06T16:10:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-02-01 PD-1 is a negative costimulator of chronic infectious diseases In this study, we investigated the expression of PD-1 and its ligands in the spleen of dogs with visceral leishmaniasis and lymphoproliferative response to soluble antigen, in lymph node cells in the presence or absence of antibodies blocking PD-1 and its ligands. Our results showed expression of PD-1 and its ligands is higher after L. infantum infection and in the spleen of infected dogs, PD-1 blockage was able to restore the antigen-dependent lymphoproliferative response and regulated production of the cytokines IL-4 and IL-10 and NO production. We concluded that L. infantum infection modulates PD-1 and its ligands expression in canine VL and that blockage of PD-1 restores the immune response. Thus, blockage of PD-1 is a target for therapeutic drug development. Cellular Immunology Laboratory Department of Medicine Surgery and Animal Reproduction School of Veterinary Medicine of Araçatuba (FMVA) Universidade Estadual Paulista “Julio de Mesquita Filho” (UNESP) Cellular Immunology Laboratory Department of Medicine Surgery and Animal Reproduction School of Veterinary Medicine of Araçatuba (FMVA) Universidade Estadual Paulista “Julio de Mesquita Filho” (UNESP) |
| Databáze: | OpenAIRE |
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