Value of stimulated pre-ablation thyroglobulin as a prognostic marker in patients with differentiated thyroid carcinoma treated with radioiodine

Autor:	Giulliana Nóbrega, Milena Cavalcanti, Verônica Leite, Lúcio Vilar, Simone Cristina Soares Brandão
Rok vydání:	2021
Předmět:	Iodine Radioisotopes Endocrinology Endocrinology Diabetes and Metabolism Thyroidectomy Humans Thyroid Neoplasms Adenocarcinoma Prognosis Thyroglobulin Retrospective Studies
Zdroj:	Endocrine. 76(3)
ISSN:	1559-0100
Popis:	To determine which Thyroglobulin (Tg) level after levothyroxine (LTA chart review was performed in which 375 patients with DTC treated with RAIT were included. The sTg was measured in all patients prior to treatment with IIncomplete response to treatment was found in 122 patients (32.5%), this group had a mean sTg of 23.2 ng/mL. ROC curve showed that the optimal cut-off sTg level was 4.4 ng/mL. (sensitivity: 72.1%; specificity: 72.3%; accuracy: 72.2%; positive predictive value of 55.7%; and negative predictive value: 84.3%).sTg pre-ablation is a valuable predictor of DTC incomplete response to treatment one year after RAIT. Levels of 4.4 ng/ml or more showed higher accuracy to predict this outcome.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba34738981135998b73c046ad589d94 https://pubmed.ncbi.nlm.nih.gov/35237910 Zobrazit plný text záznamu Full text from SpringerLink