Volitional social interaction prevents drug addiction in rat models
| Autor: | Sam A. Golden, Jennifer K. Hoots, Michelle Zhang, Conor Heins, Daniele Caprioli, Yavin Shaham, Marco Venniro, Marisela Morales, David H. Epstein |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Substance-Related Disorders media_common.quotation_subject Drug-Seeking Behavior volitional abstinence methamphetamine heroin Self Administration Craving Behavioral neuroscience Social Environment Article Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine mental disorders medicine Animals Social Behavior media_common Behavior Animal General Neuroscience Addiction Social environment Abstinence medicine.disease Housing Animal Social relation Rats Behavior Addictive Substance abuse Disease Models Animal 030104 developmental biology Conditioning Operant Female medicine.symptom Self-administration Psychology Neuroscience 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Nat Neurosci |
| ISSN: | 1546-1726 1097-6256 |
| Popis: | Addiction treatment has not been appreciably improved by neuroscientific research. One problem is that mechanistic studies using rodent models do not incorporate volitional social factors, which play a critical role in human addiction. Here, using rats, we introduce an operant model of choice between drugs and social interaction. Independent of sex, drug class, drug dose, training conditions, abstinence duration, social housing, or addiction score in Diagnostic & Statistical Manual IV-based and intermittent access models, operant social reward prevented drug self-administration. This protection was lessened by delay or punishment of the social reward but neither measure was correlated with the addiction score. Social-choice-induced abstinence also prevented incubation of methamphetamine craving. This protective effect was associated with activation of central amygdala PKCδ-expressing inhibitory neurons and inhibition of anterior insular cortex activity. These findings highlight the need for incorporating social factors into neuroscience-based addiction research and support the wider implantation of socially based addiction treatments. |
| Databáze: | OpenAIRE |
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