Protective Effect of a Mitochondria-Targeted Peptide against the Development of Chemotherapy-Induced Peripheral Neuropathy in Mice
| Autor: | Megumi Shimoyama, Peter W. Schiller, Naohito Shimoyama, Satoshi Toyama, Hazel H. Szeto |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Physiology Colorectal cancer Cognitive Neuroscience medicine.medical_treatment Peptide Antineoplastic Agents Pharmacology Mitochondrion Protective Agents Biochemistry Article 03 medical and health sciences 0302 clinical medicine medicine Animals Peripheral Nerves chemistry.chemical_classification Chemotherapy Mice Inbred BALB C Molecular Structure business.industry Peripheral Nervous System Diseases Cell Biology General Medicine medicine.disease 3. Good health Oxaliplatin Mitochondria Disease Models Animal 030104 developmental biology Peripheral neuropathy Chemotherapy-induced peripheral neuropathy chemistry Hyperalgesia Neuropathic pain Neuralgia business Oligopeptides 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | ACS chemical neuroscience. 9(7) |
| ISSN: | 1948-7193 |
| Popis: | Several chemotherapeutic agents used for cancer treatment induce dose-limiting peripheral neuropathy that compromises patients’ quality of life and limits cancer treatment. Recently, mitochondrial dysfunction has been shown to be involved in the mechanism of chemotherapy-induced peripheral neuropathy. SS-20 is a mitochondria-targeted peptide that promotes mitochondrial respiration and restores mitochondrial bioenergetics. In the present study, we examined the protective effect of SS-20 against the development of chemotherapy-induced peripheral neuropathy utilizing a murine model of peripheral neuropathy induced by oxaliplatin, a first-line chemotherapy agent for colon cancer. Weekly administrations of oxaliplatin induced peripheral neuropathy as demonstrated by the development of neuropathic pain and loss of intraepidermal nerve fibers in the hind paw. Continuous administration of SS-20 protected against the development of oxaliplatin-induced neuropathic pain and mitigated the loss of intraepidermal nerve fibers to normal levels. Our findings suggest that SS-20 may be a drug candidate for the prevention of chemotherapy-induced peripheral neuropathy. |
| Databáze: | OpenAIRE |
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