Inheritance of persistent foramen ovale and atrial septal defects and the relation to familial migraine with aura
| Autor: | W L Morrison, Simon Nightingale, Kevin Walsh, Peter Wilmshurst, Matthew Pearson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Proband
medicine.medical_specialty congenital hereditary and neonatal diseases and abnormalities genetic structures Aura Right-to-left shunt Foramen secundum Atrial septal defects Heart Septal Defects Atrial stomatognathic system Internal medicine medicine.artery Medicine Humans cardiovascular diseases Heart septal defect business.industry Congenital Heart Disease medicine.disease Migraine with aura Surgery Migraine Echocardiography Cardiology cardiovascular system medicine.symptom Cardiology and Cardiovascular Medicine business Echocardiography Transesophageal |
| Popis: | Objective: To determine whether smaller atrial shunts (large persistent foramen ovale (PFO) and small atrial septal defect (ASD)) are inherited and whether this has a role in the inheritance of migraine with aura. Methods: Contrast echocardiography was used to detect atrial shunts in 71 relatives of 20 probands with a significantly sized atrial shunt (large PFO or ASD). Four families with three generations, 14 families with two generations, and two sibships were studied. The contrast echocardiograms were performed blind to history of migraine. A consultant neurologist, who was blinded to cardiac findings, categorised migraine symptoms in subjects. Results: The occurrence of atrial shunts was consistent with autosomal dominant inheritance. Usually shunts were large PFOs, but in some cases they were ASDs. There was also evidence that inheritance of more complex congenital heart disease may be related to the inheritance of PFOs. When the proband had migraine with aura and an atrial shunt, 15 of the 21(71.4%) first degree relatives with a significant right to left shunt also had migraine with aura compared with three of 14 (21.4%) without a significant shunt (p Conclusions: There is dominant inheritance of atrial shunts. This is linked to inheritance of migraine with aura in some families. |
| Databáze: | OpenAIRE |
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