Clinical disease activity is associated with anxiety and depressive symptoms in adolescents and young adults with inflammatory bowel disease
| Autor: | J van der Burg, P. C. W. M. Hurkmans, H. van Wering, Daniëlle Hendriks, Johanna C. Escher, D Rizopolous, G. R. van den Brink, Elisabeth M. W. J. Utens, R Stuyt, L. E. Vlug, Luuk Stapersma, Alexander Bodelier |
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| Přispěvatelé: | Developmental Psychopathology (RICDE, FMG), Child Psychiatry, Pediatrics, Child and Adolescent Psychiatry / Psychology, Epidemiology |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Cross-sectional study Disease Anxiety Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine Crohn Disease Risk Factors Surveys and Questionnaires Internal medicine Prevalence medicine Humans Pharmacology (medical) 030212 general & internal medicine Young adult Child Prospective cohort study Depression (differential diagnoses) Netherlands Hepatology Depression business.industry Gastroenterology Odds ratio Inflammatory Bowel Diseases Cross-Sectional Studies Disease Progression Quality of Life Female 030211 gastroenterology & hepatology medicine.symptom business Cohort study |
| Zdroj: | Alimentary Pharmacology and Therapeutics, 48(3), 358-369. Wiley-Blackwell Alimentary pharmacology & therapeutics, 48(3), 358-369. Wiley-Blackwell Alimentary Pharmacology & Therapeutics, 48(3), 358-369. Wiley-Blackwell Publishing Ltd |
| ISSN: | 1365-2036 0269-2813 |
| Popis: | Background Youths with inflammatory bowel disease (IBD) are at risk for developing anxiety and depressive symptoms with a reported 20%-50% prevalence rate. Aims This prospective study aimed to: (1) describe the prevalence and severity of anxiety and depressive symptoms in a large Dutch cohort of young IBD patients, and (2) identify demographic and clinical risk factors for anxiety and depression. Methods IBD patients (n = 374; 10-25 years) were screened for anxiety, depression and quality of life using validated age-specific questionnaires. Patients with elevated scores for anxiety and/or depressive symptoms received a diagnostic interview assessing psychiatric disorders. Demographic and clinical characteristics were retrieved from medical charts. Multiple logistic regression analysis was performed to identify risk factors for anxiety and/or depression. Results Patients (mean age 18.9 years, 44.1% male, Crohn's disease 60.4%) had disease in remission (75.4%), or mild, moderate and severe clinical disease activity in, respectively, 19.8%, 2.7% and 2.1%. Mild anxiety/depressive symptoms were present in 35.2% and severe symptoms in 12.4% of patients. Elevated symptoms of either anxiety (28.3%), depression (2.9%) or both (15.8%) were found and did not differ between adolescents (10-17 years) and young adults (18-25 years). Active disease significantly predicted depressive symptoms (odds ratio (OR): 4.6 [95% confidence interval [CI]: 2.4-8.8], P < 0.001). Female gender (OR: 1.7 [95% CI: 1.1-2.7]), active disease (OR: 1.9 [95% CI: 1.1-3.2]) and a shorter disease duration (OR: 1.3 [95% CI: 0.6-1.0) (all P < 0.025) significantly predicted anxiety and/or depressive symptoms. ConclusionsConsidering the high prevalence of anxiety and depressive symptoms, psychological screening is recommended in young IBD patients. Screening facilitates early recognition and psychological treatment. Female patients and patients with active disease are the most vulnerable. |
| Databáze: | OpenAIRE |
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