ASSOCIATION OF SERUM TNF- A WITH INSULIN RESISTANCE IN PRE-DIABETES AND TYPE 2 DIABETES MELLITUS
| Autor: | Poorvi Gupta, Neerja Mallick, P. J. Hisalkar |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Insulin resistance Endocrinology business.industry Pre diabetes Internal medicine TNF-�� Tumor Necrosis Factor Alpha IR- Insulin Resistance T2DM- Type 2 Diabetes Mellitus PD- Pre-Diabetes medicine Type 2 Diabetes Mellitus Tumor necrosis factor alpha medicine.disease business TNF-α Tumor Necrosis Factor Alpha IR- Insulin Resistance T2DM- Type 2 Diabetes Mellitus PD- Pre-Diabetes |
| DOI: | 10.5281/zenodo.5766751 |
| Popis: | Background-First adipocyte derived biomarker istumor necrosis factor alphawhich connect the link between inflammation and diabetes. It expresses m-RNA which is contributing to the development of insulin resistance.However, the relationship between tumor necrosis factor alpha, pre-diabetes and Type2diabetes mellitus is still contradictory and restricted. Material & Methods: This study washospital based analytical cross-sectional study. Total 900 subjects were distributed into three groups (300 pre-diabetic subjects, 300 type 2 diabetic subjects and 300 healthy subjects) as per ADA criteria. The biochemical parameters as Fasting Blood Glucose, 2-hr glucose (after 75 gm oral glucose intake), HbA1c and fasting insulin were analyzed. HOMA-IR was used to calculate insulin resistance mathematically. Anthropometric measurements were done.Tumor necrosis factor alphawas done by ELISA method. Results:Tumor necrosis factor alphaconcentration was significantly increased in patients with type 2 diabetes mellitus and pre-diabetes in comparison to the control group at p value < 0.001 and showed a positive correlation with HOMA -IR. In conclusion, our findings suggested thatsystemic inflammation has an important role in the pathogenesis of pre diabetic condition. There is a progressive raises value oftumor necrosis factor alphain pre diabetic and diabetic patients. Therefore, inflammation reflects the severity of the disease and signifies the presence of ongoing disease process. |
| Databáze: | OpenAIRE |
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