Dietary Flavonoids: Cardioprotective Potential with Antioxidant Effects and Their Pharmacokinetic, Toxicological and Therapeutic Concerns
| Autor: | Somi Priya, Karla Damián Medina, Prashanta Kumar Deb, Sanjay G. Walode, Johra Khan, Rajlakshmi Devi, Mithun Rudrapal |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Antioxidant medicine.medical_treatment myocardial dysfunction Pharmaceutical Science Organic chemistry Review Antioxidants Analytical Chemistry chemistry.chemical_compound 0302 clinical medicine Flavonols QD241-441 Vegetables Drug Discovery Medicine heterocyclic compounds bioavailability and drug metabolism media_common chemistry.chemical_classification Traditional medicine food and beverages Isoflavones Cardiovascular Diseases Chemistry (miscellaneous) 030220 oncology & carcinogenesis Molecular Medicine Drug Cardiotonic Agents ROS scavenging media_common.quotation_subject Biological Availability cardioprotective effects Flavones 03 medical and health sciences Nutraceutical Humans Physical and Theoretical Chemistry Flavonoids business.industry allergology fungi toxicity Bioavailability 030104 developmental biology dietary flavonoids chemistry Polyphenol Fruit business |
| Zdroj: | Molecules, Vol 26, Iss 4021, p 4021 (2021) Molecules |
| ISSN: | 1420-3049 |
| Popis: | Flavonoids comprise a large group of structurally diverse polyphenolic compounds of plant origin and are abundantly found in human diet such as fruits, vegetables, grains, tea, dairy products, red wine, etc. Major classes of flavonoids include flavonols, flavones, flavanones, flavanols, anthocyanidins, isoflavones, and chalcones. Owing to their potential health benefits and medicinal significance, flavonoids are now considered as an indispensable component in a variety of medicinal, pharmaceutical, nutraceutical, and cosmetic preparations. Moreover, flavonoids play a significant role in preventing cardiovascular diseases (CVDs), which could be mainly due to their antioxidant, antiatherogenic, and antithrombotic effects. Epidemiological and in vitro/in vivo evidence of antioxidant effects supports the cardioprotective function of dietary flavonoids. Further, the inhibition of LDL oxidation and platelet aggregation following regular consumption of food containing flavonoids and moderate consumption of red wine might protect against atherosclerosis and thrombosis. One study suggests that daily intake of 100 mg of flavonoids through the diet may reduce the risk of developing morbidity and mortality due to coronary heart disease (CHD) by approximately 10%. This review summarizes dietary flavonoids with their sources and potential health implications in CVDs including various redox-active cardioprotective (molecular) mechanisms with antioxidant effects. Pharmacokinetic (oral bioavailability, drug metabolism), toxicological, and therapeutic aspects of dietary flavonoids are also addressed herein with future directions for the discovery and development of useful drug candidates/therapeutic molecules. |
| Databáze: | OpenAIRE |
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