Adrenergic sulfonanilides. 4. Centrally active .beta.-adrenergic agonists
| Autor: | L. E. Allen, D. L. Temple, H. C. Ferguson, William T. Comer |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Central Nervous System
Male Beta-3 adrenergic receptor Reserpine Guinea Pigs Central nervous system Adrenergic In Vitro Techniques Pharmacology Lethal Dose 50 Structure-Activity Relationship Drug Discovery Beta-Adrenergic Agonist Reaction Time medicine Animals Analgesics Sulfonamides Aniline Compounds Morphine Chemistry Quinones Seminal Vesicles Muscle Smooth Adrenergic beta-Agonists Alpha-1A adrenergic receptor Rats Trachea medicine.anatomical_structure Ethanolamines Toxicity Molecular Medicine Anorexiant Muscle Contraction medicine.drug |
| Zdroj: | Journal of Medicinal Chemistry. 19:626-633 |
| ISSN: | 1520-4804 0022-2623 |
| DOI: | 10.1021/jm00227a010 |
| Popis: | The central nervous system (CNS) activities of a number of soterenol analogs have been investigated, and several of these compounds possessed potent morphine antagonistic and anorexiant properties. The CNS activity of these compounds was enhanced by certain lipophilic [e.g., 1,1-dimethyl-2-phenethyl (43) or cyclopropyl (40 and 44)] nitrogen substituents; however, minor structural changes on either the aromatic or side-chain moieties drastically reduced central activity. Toxicity in this series was related to the inherent alpha-adrenergic stimulating component (direct or indirect). |
| Databáze: | OpenAIRE |
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