Brain structure changes visualized in early- and late-onset blind subjects
| Autor: | Patrice Voss, Natasha Lepore, Frédéric Gougoux, Yi-Yu Chou, Arthur W. Toga, Maryse Lassonde, Madeleine Fortin, Paul M. Thompson, Agatha D. Lee, C. Brun, Franco Lepore, Sarah K. Madsen |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Cognitive Neuroscience Splenium Late onset Blindness Corpus callosum Article Corpus Callosum Muscle hypertrophy White matter Young Adult Imaging Three-Dimensional Neuroimaging medicine Humans Age of Onset Brain Mapping Brain Anatomy Middle Aged medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Neurology Data Interpretation Statistical Female Occipital Lobe Psychology Occipital lobe Algorithms |
| Zdroj: | NeuroImage. 49:134-140 |
| ISSN: | 1053-8119 |
| DOI: | 10.1016/j.neuroimage.2009.07.048 |
| Popis: | We examine 3D patterns of volume differences in the brain associated with blindness, in subjects grouped according to early and late onset. Using tensor-based morphometry, we map volume reductions and gains in 16 early-onset (EB) and 16 late-onset (LB) blind adults (onset 14 years old, respectively) relative to 16 matched sighted controls. Each subject’s structural MRI was fluidly registered to a common template. Anatomical differences between groups were mapped based on statistical analysis of the resulting deformation fields revealing profound deficits in primary and secondary visual cortices for both blind groups. Regions outside the occipital lobe showed significant hypertrophy, suggesting widespread compensatory adaptations. EBs but not LBs showed deficits in the splenium and hypertrophy in the isthmus. Gains in the isthmus and non-occipital white matter were more widespread in the EBs. These differences may reflect regional alterations in late neurodevelopmental processes, such as myelination, that continue into adulthood. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect