Role of pin protrusion in the etiology of chondrolysis: a surgical model with radiographic, histologic, and biochemical analysis
| Autor: | David J. Zaleske, Andrew Sternlicht, Ann L. Armstrong, Michael G. Ehrlich |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
musculoskeletal diseases
Chondropathy Cartilage Articular medicine.medical_specialty Pathology Radiography Bone Nails Postoperative Complications medicine Animals Orthopedics and Sports Medicine Chondrolysis Osteosynthesis business.industry Cartilage Metalloendopeptidases Femur Head General Medicine Anatomy medicine.disease Acetabulum Disease Models Animal medicine.anatomical_structure Pediatrics Perinatology and Child Health Orthopedic surgery Etiology Proteoglycans Rabbits business Cartilage Diseases Peptide Hydrolases |
| Zdroj: | Journal of pediatric orthopedics. 12(4) |
| ISSN: | 0271-6798 |
| Popis: | We studied a model of pin protrusion in rabbit hips to determine if chondrolysis is produced. Enzymatic degradation of the articular cartilage remote from the pin site and mechanical destruction of the acetabulum occurred. Loss of proteoglycans in the articular cartilage averaged approximately 30%, and matched the increase in neutral protease activity. This presumably accounts for the loss of height that occurs in chondrolysis, but throughout the study, the joint space did not narrow; instead, it increased. This suggests that some other factor is needed to produce chondrolysis, such as a slip or an immune response. |
| Databáze: | OpenAIRE |
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