An analysis of two island groups as potential sites for trials of transgenic mosquitoes for malaria control
| Autor: | Amabelia Rodrigues, Parker B. Goodell, Yoosook Lee, Sarah Han, Laura C. Norris, Catelyn C. Nieman, Michelle R. Sanford, Anthony J. Cornel, Gregory C. Lanzaro, Ahmed Ouledi, Clare D. Marsden, Joao Denis |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Anopheles gambiae
030231 tropical medicine Population genetically modified mosquitoes Comoros Gene flow 03 medical and health sciences 0302 clinical medicine parasitic diseases Genetics education Bijagós Ecology Evolution Behavior and Systematics 030304 developmental biology 0303 health sciences geography education.field_of_study geography.geographical_feature_category biology Ecology island population Original Articles biology.organism_classification 3. Good health Genetically modified organism Evolutionary biology Archipelago Biological dispersal Mainland General Agricultural and Biological Sciences Genetic isolate isolation |
| Zdroj: | Evolutionary Applications |
| ISSN: | 1752-4571 |
| Popis: | Considerable technological advances have been made towards the generation of genetically modified mosquitoes for vector control. In contrast, less progress has been made towards field evaluations of transformed mosquitoes which are critical for evaluating the success of, and hazards associated with, genetic modification. Oceanic islands have been highlighted as potentially the best locations for such trials. However, population genetic studies are necessary to verify isolation. Here, we used a panel of genetic markers to assess for evidence of genetic isolation of two oceanic island populations of the African malaria vector, Anopheles gambiae s.s. We found no evidence of isolation between the Bijagos archipelago and mainland Guinea-Bissau, despite separation by distances beyond the known dispersal capabilities of this taxon. Conversely, the Comoros Islands appear to be genetically isolated from the East African mainland, and thus represent a location worthy of further investigation for field trials. Based on assessments of gene flow within and between the Comoros islands, the island of Grande Comore was found to be genetically isolated from adjacent islands and also exhibited local population structure, indicating that it may be the most suitable site for trials with existing genetic modification technologies. |
| Databáze: | OpenAIRE |
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