Relationship between obstructive sleep apnea and coronary microcirculatory function among patients with cardiac syndrome X
| Autor: | Shuai-bing Li, Yan-feng Li, Na Wang, Luo-sha Zhao, Hai-yu Li, Zhong-jian Li, Qing Zhi, Qiang-wei Shi |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
China medicine.medical_specialty Severity of Illness Index Coronary circulation stomatognathic system Risk Factors Coronary Circulation Internal medicine Cardiac syndrome X Odds Ratio Prevalence medicine Humans Obesity Prospective Studies Aged Microvascular Angina Sleep Apnea Obstructive Chi-Square Distribution business.industry Microcirculation Sleep apnea Coronary flow reserve Cholesterol LDL General Medicine Odds ratio Middle Aged medicine.disease Coronary Vessels Confidence interval nervous system diseases respiratory tract diseases Obstructive sleep apnea C-Reactive Protein Logistic Models medicine.anatomical_structure Microvessels Multivariate Analysis Cardiology Female Inflammation Mediators Cardiology and Cardiovascular Medicine business Chi-squared distribution Biomarkers |
| Zdroj: | Coronary Artery Disease. 25:35-39 |
| ISSN: | 0954-6928 |
| DOI: | 10.1097/mca.0000000000000058 |
| Popis: | Objectives Obstructive sleep apnea (OSA) is an emerging risk factor for cardiovascular disease. Microcirculatory dysfunction has been proposed as a potential mechanism in the pathogenesis of cardiovascular disease in OSA. This study aims to investigate the relationship between OSA and coronary microcirculatory function. Patients and methods One thousand and thirty-eight patients (598 female, mean age 60±9 years) with angiographically normal coronary arteries were divided into three groups with non-OSA of apnea-hypopnea index (AHI) less than 5 (n=403), mild-to-moderate OSA of AHI 5-30 (n=386), and severe OSA of AHI more than 30 (n=249). Results The prevalence of OSA was very high in patients with syndrome X (635/1038). Patients with higher AHI values had a lower coronary flow reserve, were more likely to have a higher total cholesterol, low-density lipoprotein cholesterol, and high sensitive C-reactive protein, and were more likely to be obese. Compared with the non-OSA group, the multivariable-adjusted odds ratio of coronary microcirculatory function for an AHI of 5-30 events/h was 1.93, 95% confidence interval 1.66-3.47, P=0.038, and for an AHI of more than 30 events/h was 2.18, 95% confidence interval 1.62-4.23, P=0.024, in model 1; and coronary microcirculatory function for an AHI of 5-30 events/h and more than 30 events/h odds ratio 1.31, 95% confidence interval 1.06-2.88, P=0.043, versus odds ratio 2.08, 95% confidence interval 1.03-2.16, P=0.036, in model 2. Conclusion As compared with having no sleep apnea, categories with higher AHI were associated with increased odds of lower coronary flow reserve. The data suggested a close relationship between OSA and coronary microcirculatory function in atherosclerosis. |
| Databáze: | OpenAIRE |
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