SCORE Studies on the Impact of Drug Treatment on Morbidity due to Schistosoma mansoni and Schistosoma haematobium Infection
| Autor: | Rosemary M. Musuva, Pascal Magnussen, Ye Shen, Gisele Nepomuceno de Andrade, Daniel G. Colley, Pauline N. M. Mwinzi, Ryan E. Wiegand, Sue Binder, Christopher C. Whalen, Charles H. King, Safari Kinung’hi, Carl H. Campbell, Susan P. Montgomery, Annette Olsen, Amara E. Ezeamama, William Evan Secor |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Adolescent 030231 tropical medicine MEDLINE Schistosomiasis Tanzania Praziquantel Cohort Studies 03 medical and health sciences Schistosomiasis haematobia 0302 clinical medicine Virology Internal medicine medicine Prevalence Animals Humans Mass drug administration Child Parasite Egg Count Schools biology business.industry Articles Schistosoma mansoni biology.organism_classification medicine.disease Kenya Schistosomiasis mansoni Malnutrition Infectious Diseases Systematic review Cohort Schistosoma haematobium Mass Drug Administration Schistosoma Parasitology Female Morbidity business Cohort study |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene King, C H, Binder, S, Shen, Y, Whalen, C C, Campbell, C H, Wiegand, R E, Olsen, A, Secor, W E, Montgomery, S P, Musuva, R, Mwinzi, P N M, Magnussen, P, Kinung'hi, S, Andrade, G N, Ezeamama, A E & Colley, D G 2020, ' SCORE studies on the impact of drug treatment on morbidity due to Schistosoma mansoni and Schistosoma haematobium infection ', American Journal of Tropical Medicine and Hygiene, vol. 103, no. 1_Suppl, pp. 30-35 . https://doi.org/10.4269/ajtmh.19-0830 |
| ISSN: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.19-0830 |
| Popis: | The Schistosomiasis Consortium for Operational Research (SCORE) was funded in 2008 to improve the evidence base for control and elimination of schistosomiasis—better understanding of the systemic morbidities experienced by children in schistosomiasis-endemic areas and the response of these morbidities to treatment, being essential for updating WHO guidelines for mass drug administration (MDA) in endemic areas. This article summarizes the SCORE studies that aimed to gauge the impact of MDA-based treatment on schistosomiasis-related morbidities. Morbidity cohort studies were embedded in the SCORE’s larger field studies of gaining control of schistosomiasis in Kenya and Tanzania. Following MDA, cohort children had less undernutrition, less portal vein dilation, and increased quality of life in Year 5 compared with baseline. We also conducted a pilot study of the Behavioral Assessment System for Children (BASC-2) in conjunction with the Kenya gaining control study, which demonstrated beneficial effects of treatment on classroom behavior. In addition, the SCORE’s Rapid Answers Project performed systematic reviews of previously available data, providing two meta-analyses related to morbidity. The first documented children’s infection-related deficits in school attendance and achievement and in formal tests of learning and memory. The second showed that greater reductions in egg output following drug treatment correlates significantly with reduced odds of most morbidities. Overall, these SCORE morbidity studies provided convincing evidence to support the use of MDA to improve the health of school-aged children in endemic areas. However, study findings also support the need to use enhanced metrics to fully assess and better control schistosomiasis-associated morbidity. |
| Databáze: | OpenAIRE |
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