Photodynamic Detection of Peritoneal Metastases Using 5-Aminolevulinic Acid (ALA)
| Autor: | Hiroshi Shintani, Koutarou Hatano, Haruaki Ishibashi, Yoshio Endo, Yuuki Imazato, Kousuke Noguchi, Shun-ichiro Ogura, Hiroyuki Yoshitake, Yan Li, Emel Canbay, Satoshi Wakama, Yutaka Yonemura, Akiyoshi Mizumoto, Yang Liu, Masamitu Hirano, Kazuhiro Yamada, Nobuyuki Takao, Masumi Ichinose |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Peritoneal metastasis ferrochelatase ABCG2 Photodynamic diagnosis Review lcsh:RC254-282 aminolevulinic acid 03 medical and health sciences 0302 clinical medicine Internal medicine Perioperative chemotherapy medicine PEPT1 030212 general & internal medicine peritoneal surface malignancies Terminal stage business.industry photodynamic diagnosis (PDD) Cancer medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Surgery 030220 oncology & carcinogenesis business Cytoreductive surgery |
| Zdroj: | Cancers, Vol 9, Iss 3, p 23 (2017) Cancers |
| ISSN: | 2072-6694 |
| Popis: | In the past, peritoneal metastasis (PM) was considered as a terminal stage of cancer. From the early 1990s, however, a new comprehensive treatment consisting of cytoreductive surgery and perioperative chemotherapy has been established to improve long-term survival for selected patients with PM. Among prognostic indicators after the treatment, completeness of cytoreduction is the most independent predictors of survival. However, peritoneal recurrence is a main cause of recurrence, even after complete cytoreduction. As a cause of peritoneal recurrence, small PM may be overlooked at the time of cytoreductive surgery (CRS), therefore, development of a new method to detect small PM is desired. Recently, photodynamic diagnosis (PDD) was developed for detection of PM. The objectives of this review were to evaluate whether PDD using 5-aminolevulinic acid (ALA) could improve detection of small PM. |
| Databáze: | OpenAIRE |
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