Effects of resistance training and turmeric supplementation on reactive species marker stress in diabetic rats
Autor: | Jymmys Lopes dos Santos, Ana Mara de Oliveira e Silva, Charles dos Santos Estevam, Felipe J. Aidar, Fábio Bessa Lima, Jessica Denielle Matos dos Santos, Anderson Carlos Marçal, Silvan Silva de Araújo, Ailton Santos Sena Júnior |
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Rok vydání: | 2020 |
Předmět: |
medicine.medical_specialty
Physical Therapy Sports Therapy and Rehabilitation 03 medical and health sciences chemistry.chemical_compound Diabetes mellitus 0302 clinical medicine Weight loss Internal medicine Lactate dehydrogenase medicine TBARS Orthopedics and Sports Medicine 030212 general & internal medicine lcsh:Sports medicine Type 1 diabetes medicine.diagnostic_test biology business.industry Rehabilitation Turmeric 030229 sport sciences medicine.disease Resistance training Endocrinology chemistry biology.protein Uric acid Creatine kinase medicine.symptom lcsh:RC1200-1245 Lipid profile business Research Article |
Zdroj: | BMC Sports Science, Medicine and Rehabilitation, Vol 12, Iss 1, Pp 1-12 (2020) BMC Sports Science, Medicine and Rehabilitation |
ISSN: | 2052-1847 |
Popis: | Background Type 1 diabetes mellitus (T1DM) is a metabolic disease characterized by hyperglycemia and excessive generation of reactive oxygen species caused by autoimmune destruction of beta-cells in the pancreas. Among the antioxidant compounds, Curcuma longa (CL) has potential antioxidant effects and may improve hyperglycemia in uncontrolled T1DM/TD1, as well as prevent its complications (higher costs for the maintenance of health per patient, functional disability, cardiovascular disease, and metabolic damage). In addition to the use of compounds to attenuate the effects triggered by diabetes, physical exercise is also essential for glycemic control and the maintenance of skeletal muscles. Our objective is to evaluate the effects of CL supplementation associated with moderate- to high-intensity resistance training on the parameters of body weight recovery, glycemic control, reactive species markers, and tissue damage in rats with T1DM/TD1. Methods Forty male 3-month-old Wistar rats (200–250 g) with alloxan-induced T1DM were divided into 4 groups (n = 7–10): sedentary diabetics (DC); diabetic rats that underwent a 4-week resistance training protocol (TD); CL-supplemented diabetic rats (200 mg/kg body weight, 3x a week) (SD); and supplemented diabetic rats under the same conditions as above and submitted to training (TSD). Body weight, blood glucose, and the following biochemical markers were analyzed: lipid profile, aspartate aminotransferase (AST), alanine aminotransferase (ALT), uric acid, creatine kinase (CK), lactate dehydrogenase (LDH), and thiobarbituric acid reactive substances (TBARS). Results Compared to the DC group, the TD group showed body weight gain (↑7.99%, p = 0.0153) and attenuated glycemia (↓23.14%, p = 0.0008) and total cholesterol (↓31.72%, p ≤ 0.0041) associated with diminished reactive species markers in pancreatic (↓45.53%, p p p ≤ 0.0001); attenuated glycemia (↓42.40%, p ≤ 0.0001), triglycerides (↓39.96%, p ≤ 0.001), and total cholesterol (↓28.61%, p ≤ 0.05); and attenuated the reactive species markers in the serum (↓26.92%, p ≤ 0.01), pancreas (↓46.22%, p ≤ 0.0001), cardiac (↓55.33%, p ≤ 0.001), and skeletal muscle (↓42.27%, p ≤ 0.001) tissues caused by T1DM. Conclusion Resistance training associated (and/or not) with the use of Curcuma longa attenuated weight loss, the hypoglycemic and hypolipidemic effects, reactive species markers, and T1DM-induced tissue injury. |
Databáze: | OpenAIRE |
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