[Atherosclerotic and hemorrhagic diseases in a patient with primary immune deficiency]
| Autor: | Hitoshi Kohsaka, Mari Kamiya, Makoto Soejima, Hideyuki Iwai, Nobuyuki Miyasaka |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Hyper IgM syndrome Subarachnoid hemorrhage Anti-nuclear antibody Immunology Immunoglobulin E Hemorrhagic Disorders Gastroenterology Fatal Outcome Internal medicine Immunology and Allergy Medicine Humans medicine.diagnostic_test biology business.industry Immunologic Deficiency Syndromes General Medicine Arteriosclerosis Middle Aged medicine.disease Atherosclerosis biology.protein Pulmonary Alveolar Hemorrhage Renal biopsy Antibody business |
| Zdroj: | Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology. 38(5) |
| ISSN: | 1349-7413 |
| Popis: | A 59-year-old man, who suffered from periodic fever with continuous elevation of the C-reactive protein (CRP) level was referred to our hospital. He had frequent respiratory infections and diarrhea since his childhood. The serum immunoglobulin (Ig) G level was low (537 mg/dl) while IgA and IgE were undetectable. The serum IgM level was elevated (737 mg/dl). Based on these clinical features, he was diagnosed with primary immune deficiency, hyper IgM syndrome. He had past histories of aortic aneurysm, which had been repaired surgically in his fifties. His persistent proteinuria made us to perform renal biopsy, which revealed nephrosclerotic changes. During the hospitalization, multiple events of subcortical brain hemorrhage, subarachnoid hemorrhage, and pulmonary alveolar hemorrhage occurred. Bleeding time and coagulation tests were normal. Antinuclear antibody, anti-neutrophil cytoplasmic antibody, or anti-cardiolipin antibody was absent. Herein, we described the first case of the immune deficiency associated with severe arteriosclerosis and hemorrhage. |
| Databáze: | OpenAIRE |
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