Association of frequent moisturizer use in early infancy with the development of food allergy
| Autor: | Gillian Regis, Yasmin Kahnum, Mary DeSousa, Lorna Wheatley, Ronald van Ree, Hywel C Williams, Asha Sudra, Sharon Tonner, Kerry Richards, Erin Thompson, Joanna Craven, Jason Cullen, Carsten Flohr, Suzana Radulovic, Ewa Pietraszewicz, Victoria Offord, Devi Patkunam, Tom Marrs, Emily Banks, Charlie Bigwood, Victor Turcanu, Serge A. Versteeg, Sarah Byrom, Anna Tseng, Gideon Lack, Charlotte Stedman, Katherine Taylor, Michael R. Perkin, Joanne R Chalmers, Ben Stockwell, Robert J. Boyle, Rachel Babic, Louise Young, Bunmi Raji, Kirsty Logan, Alick Stephens |
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| Přispěvatelé: | Experimental Immunology, APH - Global Health, APH - Personalized Medicine, Ear, Nose and Throat, AII - Inflammatory diseases |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
filaggrin
Pediatrics medicine.medical_specialty medicine.medical_treatment Immunology Population Moisturization law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial children law Food allergy Dry skin medicine Immunology and Allergy 030212 general & internal medicine SCORAD skin barrier education education.field_of_study food allergy medicine.diagnostic_test business.industry allergy prevention Atopic dermatitis Odds ratio medicine.disease 030228 respiratory system TEWL eczema medicine.symptom Moisturizer business |
| Zdroj: | Journal of allergy and clinical immunology, 147(3), 967-976.e1. Mosby Inc. |
| ISSN: | 0091-6749 |
| DOI: | 10.1016/j.jaci.2020.10.044 |
| Popis: | Background: Food allergy is thought to develop through transcutaneous sensitization, especially in the presence of skin barrier impairment and inflammation. Regular moisturizer application to infant skin could potentially promote transcutaneous sensitization and the development of food allergy. Objectives: We tested this hypothesis in the Enquiring About Tolerance (EAT) study population. Methods: The EAT study was a population-based randomized clinical trial conducted from January 15, 2008, to August 31, 2015, and recruited 1303 exclusively breastfed 3-month-old infants and their families from England and Wales. At enrollment at 3 months, families completed a questionnaire that included questions about frequency and type of moisturizer applied, use of corticosteroid creams, and parental report of dry skin or eczema. Infants were examined for visible eczema at the enrollment visit. Results: A statistically significant dose-response relationship was observed between parent-reported moisturization frequency at 3 months of age and the subsequent development of food allergy. Each additional moisturization per week was associated with an adjusted odds ratio of 1.20 (95% CI, 1.13-1.27; P |
| Databáze: | OpenAIRE |
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