An unlikely role for the NAT2 genotypes and haplotypes in the oral cancer of south Indians
| Autor: | Lakshmi Balaji, Bhaskar L.V.K.S., Balaji Singh Krishna |
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| Rok vydání: | 2011 |
| Předmět: |
Risk
Genotype Arylamine N-Acetyltransferase India Single-nucleotide polymorphism Biology medicine.disease_cause Polymorphism Single Nucleotide Asian People Gene Frequency medicine Humans Genetic Predisposition to Disease Allele General Dentistry Allele frequency Carcinogen Genetics Chi-Square Distribution Haplotype Cell Biology General Medicine Minor allele frequency Logistic Models Phenotype Otorhinolaryngology Haplotypes Case-Control Studies Carcinoma Squamous Cell Mouth Neoplasms Carcinogenesis |
| Zdroj: | Archives of oral biology. 57(5) |
| ISSN: | 1879-1506 |
| Popis: | The arylamine N-acetyltransferase 2 (NAT2) enzyme detoxifies a wide spectrum of naturally occurring xenobiotics including carcinogens and drugs. Acetylation catalysed by the NAT2 is an important process in metabolic activation of arylamines to electrophilic intermediates that initiate carcinogenesis. Polymorphism in N-acetyltransferase 2 gene was reported to be associated with the susceptibility of various cancers. Objective The aim of our study was to determine whether there is any association between the susceptibility to oral cancer amongst the variations of NAT2 genotypes. Design This study was carried out in 157 patients with oral cancer. The control group consisted of 132 healthy volunteers. The most common polymorphisms rs1799929, rs1799930 and rs1799931 on the NAT2 gene were screened for the genotypes using TaqMan allelic discrimination. Results All the three SNPs were polymorphic with minor allele frequency of 0.339, 0.372 and 0.061 for rs1799929, rs1799930 and rs1799931, respectively. None of the polymorphic site deviated from HWE in controls. There were no significant differences in genotype or allele frequencies of three SNPs between controls and cases with oral cancer. Risk of oral cancer development for the carriers of the individual deduced phenotypes was also not statistically significant. Of the 3 studied polymorphisms, 2 were in strong LD and form one haplotype block. None of the haplotype had shown significant association with the oral cancer. Conclusions Our study concludes that the NAT2 genotypes, phenotypes and haplotypes are not involved in the susceptibility to oral cancer in South Indian subjects. |
| Databáze: | OpenAIRE |
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