Amino Acid Residues Affecting Drug Pump Function in Candida albicans-C. albicans Drug Pump Function
| Autor: | Richard D. Cannon, Koichi Tanabe, Masakazu Niimi, Ann R. Holmes, Brian C. Monk, Erwin Lamping, Sarah Tsao, Kyoko Niimi |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Drug
chemistry.chemical_classification biology media_common.quotation_subject Human pathogen ATP-binding cassette transporter biology.organism_classification Microbiology Amino acid Multiple drug resistance Infectious Diseases Biochemistry chemistry Drug Resistance Multiple Fungal Candida albicans ATP-Binding Cassette Transporters Amino Acid Sequence Efflux Amino Acids Peptide sequence media_common |
| Zdroj: | Nippon Ishinkin Gakkai Zasshi. 47:275-281 |
| ISSN: | 1882-0476 0916-4804 |
| DOI: | 10.3314/jjmm.47.275 |
| Popis: | Membrane-located drug transporters are important components in the multidrug resistance of microbial cells and human tissues. In fungi, clinically important resistance to antifungal drugs most often results from the over-expression of efflux pump proteins in the plasma membrane of the resistant cell. This review describes studies of the ATP binding cassette (ABC) family of membrane efflux pumps in the opportunistic human pathogen Candida albicans and, in particular, examines how changes in the polypeptide sequence can affect pump function. The identification of amino acid residues affecting pump function can provide new insights into efflux pump mechanisms and the relationship between structure and function. Such information will be important for the design of pump inhibitors which could supplement existing antifungal drugs. |
| Databáze: | OpenAIRE |
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