Mutation of a nucleosome compaction region disrupts Polycomb-mediated axial patterning

Autor:	Clifford J. Tabin, Sharmistha Kundu, Sharon K. Marr, Ruslan I. Sadreyev, Peggy I. Wang, Andrej J. Savol, Matthew G. Schwartz, Daniel J. Grau, Patrick Schorderet, Robert E. Kingston, Mei Sheng Lau
Rok vydání:	2017
Předmět:	0301 basic medicine Body Patterning macromolecular substances Biology medicine.disease_cause Article Cell Line Mice 03 medical and health sciences medicine Animals Gene silencing Nucleosome Gene Silencing Hox gene Psychological repression Skeleton Polycomb Repressive Complex 1 Genetics Mutation Multidisciplinary Genes Homeobox Gene Expression Regulation Developmental Mice Mutant Strains Nucleosomes Cell biology 030104 developmental biology PRC1 Homeotic gene Protein Binding
Zdroj:	Science. 355:1081-1084
ISSN:	1095-9203 0036-8075
Popis:	Polycomb group gene silencing Histone proteins wrap around DNA to form nucleosomes that package metazoan DNA into the nucleus. Chromatin compaction is also believed to be critical for the repression of homeotic genes by the Polycomb repressive complex 1 (PRC1) during development. Lau et al. used mutagenesis and expression analyses to examine this gene silencing mechanism. Altering the PRC1 compaction region affected transcriptional repression and patterning of the mouse body axis. Thus, chromatin compaction may drive the stable and heritable silencing of genes involved in body patterning. Science , this issue p. 1081
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8a8bba1e08f492c70f543203520073 https://doi.org/10.1126/science.aah5403 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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