Effects of beta-adrenoceptor-blockade on stress-induced adrenocorticotrophin release in humans
| Autor: | R Oberbeck, Roland Jacobs, T. H. Schürmeyer, Manfred Schedlowski, B Sommer, R J Benschop, Reinhold E. Schmidt |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Epinephrine Hydrocortisone Physiology Adrenergic beta-Antagonists Adrenocorticotropic hormone Propranolol Placebo Norepinephrine (medication) Norepinephrine Adrenocorticotropic Hormone Double-Blind Method Physiology (medical) Internal medicine medicine Humans Orthopedics and Sports Medicine Chemistry Public Health Environmental and Occupational Health Antagonist General Medicine Endocrinology Catecholamine Stress Psychological medicine.drug |
| Zdroj: | European journal of applied physiology and occupational physiology. 77(6) |
| ISSN: | 0301-5548 |
| Popis: | We investigated the mechanisms of stress-induced alterations in adrenocorticotrophin (ACTH) release. Tandem parachutists received either a placebo or the beta-adrenoceptor antagonist propranolol prior to a first time parachute jump. Blood samples were drawn 4 h before, immediately after, and 1 h after the jump. Cortisol and catecholamine concentrations displayed a significant stress-induced increase in both groups. The ACTH plasma concentrations significantly increased in the placebo and the propranolol group, with significantly more pronounced changes in the propranolol-treated subjects compared to the placebo group. These data demonstrated a stress-induced increase of ACTH plasma concentrations in humans that was enhanced by beta-blockade. |
| Databáze: | OpenAIRE |
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