Promoter Methylation of E-Cadherin, p16, and RAR-β2Genes in Breast Tumors and Dietary Intake of Nutrients Important in One-Carbon Metabolism

Autor:	Joel B. Mason, Stephen B. Edge, Susan E. McCann, Maurizio Trevisan, Jo L. Freudenheim, Amy E. Millen, Mary E. Platek, Christine B. Ambrosone, Shiva Krishnan, Catalin Marian, Peter G. Shields, Meng-Hua Tao
Rok vydání:	2011
Předmět:	Adult Cancer Research medicine.medical_specialty Receptors Retinoic Acid Population New York Medicine (miscellaneous) Breast Neoplasms Biology medicine.disease_cause Article chemistry.chemical_compound Folic Acid Methionine Surveys and Questionnaires Internal medicine Odds Ratio medicine Humans Promoter Regions Genetic education Gene Cyclin-Dependent Kinase Inhibitor p16 Aged education.field_of_study Nutrition and Dietetics Cadherin Case-control study Odds ratio DNA Methylation Middle Aged Cadherins Diet Logistic Models Endocrinology Oncology chemistry Case-Control Studies Vitamin B Complex DNA methylation Female Carcinogenesis
Zdroj:	Nutrition and Cancer. 63:1143-1150
ISSN:	1532-7914 0163-5581
Popis:	Aberrant DNA methylation plays a critical role in carcinogenesis, and the availability of dietary factors involved in 1-carbon metabolism may contribute to aberrant DNA methylation. We investigated the association of intake of folate, vitamins B(2), B(6), B(12), and methionine with promoter methylation of E-cadherin, p16, and RAR-β(2) genes in archived tumor tissues from incident, primary breast cancer cases in a population-based case-control study. Real-time methylation-specific PCR was performed on 803 paraffin-embedded samples; usual dietary intake was queried from a food frequency questionnaire. Unconditional logistic regression was used to derive adjusted odds ratios and 95% confidence intervals for likelihood of promoter methylation for high compared to low intake of those 1-carbon nutrients. Overall, in case-case comparisons, dietary intakes of folate, vitamins B(2), B(6), B(12), and methionine were not associated with likelihood of promoter methylation of E- cadherin, p16, and RAR-β(2) for all cases combined or within strata defined by menopausal status and estrogen receptor status in this study. This finding, however, does not exclude the possibility that intake of such nutrients might have the ability to modulate promoter methylation in normal or premalignant (dysplastic) breast tissue.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b877ac0728ac5358c871a62269f5b81 https://doi.org/10.1080/01635581.2011.605982 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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