Biomineral Nano-Theranostic agent for Magnetic Resonance Image Guided, Augmented Radiofrequency Ablation of Liver Tumor

Autor: Genekehal Siddaramana Gowd, Shantikumar V. Nair, Anusha Ashokan, Rupal B. Jobanputra, Giridharan Loghanathan Malarvizhi, Ida M. Anna, Reshmi Peethambaran, Badrinathan Sridharan, Manzoor Koyakutty, A.K.K. Unni, Vijay Harish Somasundaram
Rok vydání: 2017
Předmět:
Calcium Phosphates
Radiofrequency ablation
lcsh:Medicine
Contrast Media
Nanoparticle
02 engineering and technology
Magnetic Resonance Imaging
Interventional
01 natural sciences
Theranostic Nanomedicine
law.invention
Rats
Sprague-Dawley
Mice
law
Materials Testing
lcsh:Science
Multidisciplinary
medicine.diagnostic_test
Liver Neoplasms
Glioma
021001 nanoscience & nanotechnology
Liver
Thermography
Radiology
0210 nano-technology
medicine.medical_specialty
Liver tumor
Materials science
Iron
010402 general chemistry
Article
Cell Line
In vivo
Cations
medicine
Animals
Humans
Distribution (pharmacology)
Rats
Wistar
Radiofrequency Ablation
Blood Cells
lcsh:R
Cancer
Magnetic resonance imaging
medicine.disease
Rats
0104 chemical sciences
Nanoparticles
lcsh:Q
Neoplasm Transplantation
Biomedical engineering
Zdroj: Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
ISSN: 2045-2322
DOI: 10.1038/s41598-017-14976-8
Popis: Theranostic nanoparticles based on biocompatible mineral compositions can significantly improve the translational potential of image guided cancer nano-therapy. Here, we report development of a single-phase calcium phosphate biomineral nanoparticle (nCP) with dual-mode magnetic resonance contrast (T1-T2) together with radiofrequency (RF) mediated thermal response suitable for image-guided RF ablation of cancer. The nanoparticles (NP) are engineered to provide dual MR contrast by an optimized doping concentration (4.1 at%) of paramagnetic ion, Fe3+, which also renders lossy dielectric character for nCP leading to thermal response under RF exposure. In vivo compatibility and dual-mode MR contrast are demonstrated in healthy rat models. MRI and T2 mapping suggest hepatobiliary clearance by ~96 hours. MRI guided intratumoral injection in subcutaneous rat glioma and orthotopic liver tumor models provide clear visualization of NP in MRI which also helps in quantifying NP distribution within tumor. Furthermore, by utilising RF mediated thermal response, NP treated tumor could be ablated using clinically approved RF ablation system (10 W,13.3 GHz). Real-time in vivo thermal imaging exhibits 119 ± 10% increase in temperature change (ΔT) for NP treated orthotopic liver tumor (ΔT = 51.5 ± 2 °C), compared to untreated healthy liver control (ΔT = 21.5 ± 2 °C). In effect, we demonstrate a promising nano-biomineral theranostic agent for dual-mode MRI combined with radiofrequency ablation of solid tumors.
Databáze: OpenAIRE
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