Regioselective Aromatic Substitution of 6,8-Dihydroxy-4-ethoxycarbonyl- 2H-isoquinolin-1-one Derivatives Using the Stille Coupling Reaction

Autor:	Yutaka Yamamoto, Mikako Ono, Hidekazu Ouchi, Yasuo Morita, Yoko Kawata, Hiroki Takahata
Rok vydání:	2004
Předmět:	Pharmacology Chemistry Organic Chemistry Organic chemistry Halogenation Regioselectivity General Medicine Electrophilic aromatic substitution Medicinal chemistry Analytical Chemistry Stille reaction
Zdroj:	HETEROCYCLES. 62:491
ISSN:	0385-5414
DOI:	10.3987/com-03-s(p)43
Popis:	The novel synthesis of 6- or 7-aromatic substituted 2H-isoquinolin-1-ones, by two different routes is described. In the first route, 7-substituted derivatives were prepared by regioselective iodination at the 7-position of 6,8-dihydroxy-4-ethoxycarbonyl-2H-isoquinolin-1-one derivatives (1) followed by the Stille coupling reaction. In the second route, 6-subsutituted derivatives were prepared by the selective triflation of the 6-hydroxy group of 1 followed by the Stille coupling reaction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b82ad588efe684cf39b2dcf39435bbf https://doi.org/10.3987/com-03-s(p)43 Zobrazit plný text záznamu