Regulation of the postnatal development of dopamine neurons of the substantia nigrain vivoby Akt/protein kinase B
| Autor: | Amy Baohan, Robert E. Burke, Ross J. Bland, Hsiao-Chun Cheng, Tatyana Kareva, Nikolai Kholodilov, Vincent Ries, Matthew J. During, Tinmarla F. Oo, Margarita Rzhetskaya |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Dopamine Neurogenesis Genetic Vectors Growth Cones Apoptosis Substantia nigra Biochemistry Article Rats Sprague-Dawley Cellular and Molecular Neuroscience Transduction Genetic Neurotrophic factors Neural Pathways medicine Animals Protein kinase A Protein kinase B PI3K/AKT/mTOR pathway Cell Proliferation Cell Size Neurons biology Cell Differentiation Immunohistochemistry Rats Substantia Nigra medicine.anatomical_structure Animals Newborn nervous system biology.protein Neuron Proto-Oncogene Proteins c-akt Neuroscience Neurotrophin |
| Zdroj: | Journal of Neurochemistry. 110:23-33 |
| ISSN: | 1471-4159 0022-3042 |
| Popis: | Following mitosis, specification and migration during embryogenesis, dopamine neurons of the mesencephalon undergo a postnatal naturally occurring cell death event that determines their final adult number, and a period of axonal growth that determines pattern and extent of target contacts. While a number of neurotrophic factors have been suggested to regulate these developmental events, little is known, especially in vivo, of the cell signaling pathways that mediate these effects. We have examined the possible role of Akt/Protein Kinase B by transduction of these neurons in vivo with adeno-associated viral vectors to express either a constitutively active or a dominant negative form of Akt/protein kinase B. We find that Akt regulates multiple features of the postnatal development of these neurons, including the magnitude of the apoptotic developmental cell death event, neuron size, and the extent of target innervation of the striatum. Given the diversity and magnitude of its effects, the regulation of the development of these neurons by Akt may have implications for the many psychiatric and neurologic diseases in which these neurons may play a role. |
| Databáze: | OpenAIRE |
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