| Autor: |
Chen Shuhui, Qingming Guo, Hao Fei, Xiujuan Chang, Fusen Lin, Zhang Xiao, Xuyang Shi, Chunyan Du, Haiying He, Jun Yu, Xiao Wei, Wang Zhenzhong, Li Wang, Liang Shen, Li Peng, Jiao Hu, Deming Xu, Hu Guoping, Xinsheng Chen, Jian Li, Zhengxian Gu, Tianwei Lin, Ya Sun, Xuyang Tian |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
ACS Medicinal Chemistry Letters. 8:841-846 |
| ISSN: |
1948-5875 |
| Popis: |
Enterovirus 71 (EV71) is a major causative agent of hand, foot, and mouth disease (HFMD), which can spread its infections to the central nervous and other systems with severe consequences. The viral caspid protein VP1 is a well-known target for antiviral efficacy because its occupancy by suitable compounds could stabilize the virus capsid, thus preventing uncoating of virus for RNA release. In this Letter, design, synthesis, and biological evaluation of novel anti-EV71 agents (aminopyridyl 1,2,5-thiadiazolidine 1,1-dioxides) are described. One of the most promising compounds (14) showed excellent antiviral activity against EV71 (EC50 = 4 nM) and exhibited excellent in vivo efficacy in the EV71 infected mouse model. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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