Fabrication and characterization of hydrocortisone loaded Dextran-Poly Lactic-co-Glycolic acid micelle
| Autor: | Aram Rezaie, Shifteh Malekhosseini, Leila Behbood, Amin Hosseini, Mohadese Abdoli, Salar Khaledian, Mohammad Mahdi Zangeneh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Hydrocortisone Dispersity Micelle Dosage form Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Copolymer lcsh:Social sciences (General) lcsh:Science (General) Glycolic acid Multidisciplinary MTT assay Physics Health sciences Materials science Bioavailability Chemistry Biological sciences 030104 developmental biology Dextran chemistry Critical micelle concentration Drug delivery lcsh:H1-99 030217 neurology & neurosurgery Nuclear chemistry lcsh:Q1-390 |
| Zdroj: | Heliyon Heliyon, Vol 6, Iss 5, Pp e03975-(2020) |
| ISSN: | 2405-8440 |
| Popis: | A nanomicelle based drug delivery systems is a formulation that can improve the bioavailability and dissolution rate of water-insoluble drugs. In this study, the Dextran-Poly Lactic-co-Glycolic Acid copolymer was synthesized with esterification reaction, confirmed using the fourier-transform infrared spectroscopy and nuclear magnetic resonance. The used method for nanomicelle preparation was nanoprecipitation and the critical micelle concentration value was obtained 10 μg/mL. The particle size of the nanomicelle was less than 100 nm ± 4 nm with narrow size distribution (Polydispersity index = 0.06). Hydrocortisone was loaded to this system. The obtained results for the encapsulation efficiency were 79%, and the drug release was adjusted to a first-order kinetic model with 90% release of drug within the 12 h. The MTT assay showed that even in the high concentration of micelle, the cell viability was remained higher than 90%. Considering the toxicity investigation findings, the Dextran-Poly Lactic-co-Glycolic Acid micellar systems can be suggested as a considerable drug delivery system in hydrocortisone pharmaceutical dosage forms. Micelle; Copolymer; Hydrocortisone; MTT assay; Physics; Materials science; Chemistry; Biological sciences; Health sciences. |
| Databáze: | OpenAIRE |
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