Platelet anti-aggregatory effects of coumarins from the roots ofAngelica genuflexa andA. gigas
| Autor: | Yong Yook Lee, Hye Sook Yun-Choi, Sang-Hyun Lee, Jingling Jin |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Blood Platelets
Male Platelet Aggregation Platelet aggregation Herbal Medicine Plant Roots Rats Sprague-Dawley chemistry.chemical_compound Isooxypeucedanin Glucosides Coumarins Nephelometry and Turbidimetry Furocoumarins Drug Discovery Decursinol angelate Animals Benzopyrans Platelet Angelica Medicine East Asian Traditional Arachidonic Acid Korea Angelica genuflexa Aspirin Traditional medicine biology Plant Extracts Methanol Organic Chemistry biology.organism_classification Rats Butyrates chemistry Coagulation 15-Hydroxy-11 alpha 9 alpha-(epoxymethano)prosta-5 13-dienoic Acid Molecular Medicine Arachidonic acid Collagen Heterocyclic Compounds 3-Ring Osthol Platelet Aggregation Inhibitors |
| Zdroj: | Archives of Pharmacal Research. 26:723-726 |
| ISSN: | 1976-3786 0253-6269 |
| DOI: | 10.1007/bf02976681 |
| Popis: | Five coumarins, isoimperatorin (1), pabulenol (2), isooxypeucedanin (3), oxypeucedanin hydrate (4) and osthol (5) were isolated from the MeOH extract of Angelica genuflexa in the course of searching for anti-platelet and anti-coagulant components from plants. Pabulenol (2) was isolated from A. genuflexa for the first time. The five compounds isolated from A. genuflexa, together with decursinol angelate (6), decursin (7) and nodakenin (8) from A. gigas were evaluated for their effects on platelet aggregation and blood coagulation. Compounds 2, 5, 6 and 7 were observed to be either equally effective or 2-4 times more inhibitory than ASA in both arachidonic acid and U46619 (TXA2 mimetic) induced platelet aggregations. |
| Databáze: | OpenAIRE |
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