Evidence for antioxidant and anti‐inflammatory potential of mango (Mangifera indicaL.) in naproxen‐induced gastric lesions in rat
| Autor: | Carla Catiúscia Ferreira Gomes, Raimundo Wilane de Figueiredo, Kirley Marques Canuto, Paulo Riceli Vasconcelos Ribeiro, Delane C. Rodrigues, Kaliana Sitonio Eça, Antoniella Souza Gomes Duarte, Luciana de Siqueira Oliveira |
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| Přispěvatelé: | CARLA CATIÚSCIA FERREIRA GOMES, Department of Food Engineering, Federal University of Ceara, LUCIANA DE SIQUEIRA OLIVEIRA, Department of Food Engineering, Federal University of Ceara, DELANE C. RODRIGUES, Department of Food Engineering, Federal University of Ceara, PAULO RICELI VASCONCELOS RIBEIRO, CNPAT, KIRLEY MARQUES CANUTO, CNPAT, ANTONIELLA SOUZA GOMES DUARTE, Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceara, KALIANA SITONIO EÇA, Department of Food Engineering, Federal University of Ceara, Department of Food Engineering, Federal University of Ceara. |
| Rok vydání: | 2021 |
| Předmět: |
Antioxidant
medicine.drug_class Compostos bioativos medicine.medical_treatment Anti-Inflammatory Agents Biophysics Efeito antioxidante Propriedades antioxidantes Antioxidants Anti-inflammatory chemistry.chemical_compound Naproxen Phenols Oxidation medicine Animals Mangifera Enzyme activity Food science Gallic acid Pharmacology ABTS biology Plant Extracts Cell Biology Glutathione Malondialdehyde Lipids Rats Atividades antioxidantes Mangifera Indica chemistry Fruit Myeloperoxidase biology.protein Antiinflamatórios Food Science |
| Zdroj: | Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA-Alice) Empresa Brasileira de Pesquisa Agropecuária (Embrapa) instacron:EMBRAPA |
| ISSN: | 1745-4514 0145-8884 |
| DOI: | 10.1111/jfbc.13880 |
| Popis: | This study investigated the anti-inflammatory and antioxidant effects of hydroalcoholic extracts of mango peel and pulp on oxidative damage in a naproxen-induced gastric injury rat model. The extracts were assessed for antioxidant activity (ABTS and FRAP methods), and the phenolic profile was investigated with UPLC-QToF-MSE . Gastric damage was evaluated in vivo by assessing the membrane lipid peroxidation (malondialdehyde (MDA) content), myeloperoxidase (MPO) enzyme activity, and glutathione (GSH) content. Mango peel and pulp contained high contents of bioactive compounds, particularly phenolics (69.50-5.287.70 mg gallic acid equivalents/100 g), carotenoids (651.30-665.50 μg/100 g), and vitamin C (21.59-108.19 mg/100 g). UPLC-QToF-MSE analysis identified 17 phenol compounds, including gallotannins, glycosylated flavonoids, and xanthone. The hydroalcoholic extracts of mango peel and pulp (LPe and LPu, respectively) significantly reduced the MPO activity and MDA content. In addition to preventing naproxen-induced GSH decline, LPe (30 mg/kg) and LPu (10 mg/kg) restored its content to normal levels. LPe and LPu neutralized the oxidizing agents triggered by naproxen and reduced the severity of gastric lesions owing to their antioxidant properties. |
| Databáze: | OpenAIRE |
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