Localization of the Rev-ErbA orphan receptors in the brain
| Autor: | Tommi Kainu, Eva Enmark, Jan-Åke Gustafsson, M. Pelto-Huikko |
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| Rok vydání: | 1996 |
| Předmět: |
Male
Superior Colliculi Transcription Genetic Hypothalamus Receptors Cytoplasmic and Nuclear Receptors Cell Surface Biology Hippocampus Rats Sprague-Dawley Cerebellum Cortex (anatomy) medicine Animals Receptor Molecular Biology Brain Chemistry Orphan receptor Genes erbA General Neuroscience Olfactory Bulb Frontal Lobe Rats Olfactory bulb Stria terminalis medicine.anatomical_structure Nuclear receptor Neurology (clinical) Brainstem Neuroscience Rev-ErbA Developmental Biology |
| Zdroj: | Brain Research. 743:315-319 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/s0006-8993(96)00507-0 |
| Popis: | In the present study, we report the localization of the Rev-ErbA alpha and beta nuclear orphan receptors, two closely related members of the nuclear hormone receptor superfamily, in the brain. Both Rev-ErbA variant mRNAs were highly expressed in the olfactory bulb, the hippocampus, and in the granular cells of the cerebellum, areas enriched also in other nuclear orphan receptors. Furthermore, the alpha-isoform was found in high amounts in the frontal cortex, the superficial gray layer of the superior colliculus, and the stria terminalis. Lower expression was observed in the nucleus accumbens, the caudate-putamen, and in some thalamic and brainstem nuclei. The beta-variant, in contrast, was only moderately expressed in the cortex, mainly in the striate and retrosplenial cortices. In addition, moderate levels of Rev-ErbA beta mRNA were seen in various thalamic, pontine and brainstem nuclei. We conclude that the two Rev-ErbA isoforms share a partly similar pattern of expression in the brain, especially in areas that also contain other nuclear orphan receptors and that otherwise the localization of the two receptor subtypes is differential. |
| Databáze: | OpenAIRE |
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