Control of allergic reactions in mice by an active anti-murine IL-4 immunization

Autor:	Silvia Schnyder-Candrian, Isabelle Couillin, Robert C. Gallo, Armand Bensussan, Daniel Zagury, Gabriel Peltre, Hélène Le Buanec, Bernard Ryffel, Patrick Larcier, Sébastien Paturance, Arsène Burny, Bernard Bizzini
Přispěvatelé:	Immunologie et Embryologie Moléculaires (IEM), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)
Rok vydání:	2007
Předmět:	Allergy Immunogen medicine.medical_treatment MESH: Adjuvants Immunologic Immunoglobulin E MESH: Recombinant Proteins Mice 0302 clinical medicine Medicine MESH: Animals Lung MESH: Immunoglobulin G Mice Inbred BALB C 0303 health sciences biology MESH: Neutralization Tests MESH: Immunoglobulin E Recombinant Proteins 3. Good health MESH: Hemocyanin Vaccination Infectious Diseases Cytokine medicine.anatomical_structure [SDV.IMM]Life Sciences [q-bio]/Immunology Molecular Medicine Female MESH: Allergens Ovalbumin MESH: Hypersensitivity MESH: Mice Inbred BALB C chemical and pharmacologic phenomena 03 medical and health sciences Adjuvants Immunologic MESH: Eosinophils Neutralization Tests Hypersensitivity Animals MESH: Lung MESH: Mice Interleukin 4 030304 developmental biology MESH: Ovalbumin General Veterinary General Immunology and Microbiology business.industry Public Health Environmental and Occupational Health Allergens Antigens Plant MESH: Interleukin-4 Eosinophil medicine.disease Eosinophils Immunization Immunoglobulin G Hemocyanins Immunology biology.protein Interleukin-4 business MESH: Female 030215 immunology
Zdroj:	Vaccine Vaccine, Elsevier, 2007, 25 (41), pp.7206-16. ⟨10.1016/j.vaccine.2007.07.029⟩
ISSN:	0264-410X
DOI:	10.1016/j.vaccine.2007.07.029
Popis:	Pathogenesis of allergic inflammatory disorders is characterized by allergen-induced IgE stimulated by Th2 cytokines including mainly IL-4 overproduction. To counteract IL-4 effects in sensitized-BALB/c mice, we prepared an IL-4 derivative immunogen, made of KLH and murine IL-4 heterocomplex, termed mIL-4 kinoid. Murine IL-4 kinoid immunized mice produced high titer of anti-IL-4 neutralizing Abs. In contrast to KLH control immunization kinoid immunization reversed the allergic IgE:IgG ratio hallmark in rBet v 1a sensitized mice and reduced pulmonary eosinophil recruitment and bronchial hyperreactivity in Ova-sensitized mice. These data pave the way to alternative therapies to combat allergic conditions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b795ca77593a13f2f3783b26120831c https://doi.org/10.1016/j.vaccine.2007.07.029 Zobrazit plný text záznamu Full Text from ScienceDirect