Predictive multi-imaging biomarkers relevant for visual acuity in idiopathic macular telangiectasis type 1

Autor: Wei Liu, Haixiang Wu, Gezhi Xu, Yongjin Zhang, Xiaofeng Ye, Wenyi Tang, Jingli Guo
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
Visual acuity
genetic structures
Computed Tomography Angiography
Visual Acuity
Multimodal Imaging
chemistry.chemical_compound
0302 clinical medicine
lcsh:Ophthalmology
Fluorescein Angiography
External limiting membrane
Macular telangiectasia
medicine.diagnostic_test
General Medicine
Ellipsoid zone disruption
Middle Aged
Fluorescein angiography
medicine.anatomical_structure
Female
Retinal Telangiectasis
Macular telangiectasia type 1
medicine.symptom
Tomography
Optical Coherence
Research Article
Adult
medicine.medical_specialty
Macular Edema
03 medical and health sciences
Ophthalmology
medicine
Humans
Macular edema
Aged
Retrospective Studies
business.industry
Fundus photography
Retinal Vessels
Retinal
medicine.disease
Disorganization of the retinal inner layers
eye diseases
Optical coherence tomography angiography
chemistry
lcsh:RE1-994
030221 ophthalmology & optometry
sense organs
business
030217 neurology & neurosurgery
Biomarkers
Zdroj: BMC Ophthalmology, Vol 18, Iss 1, Pp 1-7 (2018)
BMC Ophthalmology
ISSN: 1471-2415
DOI: 10.1186/s12886-018-0737-y
Popis: Background To evaluate the structural changes associated with visual acuity (VA) in patients with idiopathic macular telangiectasia (MT) type 1 using multimodal imaging modalities. Methods A retrospective study of 14 patients with MT type 1 and of 10 eyes from 10 healthy individuals as age-matched controls was conducted. The medical records of patients who had undergone colour fundus photography, spectral domain optical coherence tomography (OCT), fluorescein angiography and OCT angiography were reviewed. Central macular thickness (CMT), the areas of macular oedema and ellipsoid zone (EZ) disruption, EZ length, disorganization of the retinal inner layers (DRIL) and external limiting membrane (ELM) disruption, as measured by spectral domain OCT; and vascular density and the foveal avascular zones (FAZ) of the superficial capillary plexus (SCP) and deep capillary plexus (DCP), as measured by OCT angiography, were assessed in MT type 1 eyes and correlated with VA. Results The mean baseline best-corrected VA of MT type 1 eyes was 0.45 ± 0.28. The mean CMT was 385.19 ± 75.21 μm in MT type 1 eyes and 252.43 ± 15.77 μm in contralateral eyes (Z = − 4.113, p
Databáze: OpenAIRE
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