Teratologic studies on rat perinates and offspring from dams treated with ethylnitrosourea (ENU)
| Autor: | Kunio Doi, Noriaki Ishigami, Wijit Kiatipattanasakul, Michio Suzuki, Ryoichi Ohtsuka, Kei-ichi Katayama, Hiroyuki Nakayama |
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| Rok vydání: | 2000 |
| Předmět: |
Tail
medicine.medical_specialty Programmed cell death Offspring Apoptosis Biology General Biochemistry Genetics and Molecular Biology Pregnancy Internal medicine Forelimb Toxicity Tests otorhinolaryngologic diseases medicine Animals Cerebral Cortex Fetus Fetal Growth Retardation General Veterinary Body Weight Abnormalities Drug-Induced General Medicine Organ Size medicine.disease Teratology Rats Inbred F344 Rats body regions Endocrinology Teratogens Animals Newborn Fetal Weight Ethylnitrosourea Severe intrauterine growth retardation Gestation Animal Science and Zoology Female sense organs |
| Zdroj: | Experimental animals. 49(3) |
| ISSN: | 1341-1357 |
| Popis: | Ethylnitrosourea (ENU), a well known DNA alkylating agent, induces anomalies in the central nervous system (CNS), craniofacial tissues, limbs and male reproductive organs. Recently we clarified that excess cell death caused by apoptosis occurred in these organs and tissues of rat fetuses from dams treated with ENU at day 13 of gestation (GD13). In this study, we examined fetuses at GD21 and offspring at 10 weeks of age after ENU administration to pregnant rats at GD13 in order to clarify the relationship between ENU-induced apoptosis in the fetal tissues and teratogenicity of ENU. Severe intrauterine growth retardation was observed in the ENU group, and the body weight of the offspring in the ENU group was significantly lower than that of the control group throughout the experiment. In addition, a high incidence of microencephaly, ectrodactyly and curved caudal vertebrae was observed in the offspring from dams treated with ENU at GD13. Judging from the results of our previous and present studies, it was strongly suggested that ENU-induced apoptosis in rat fetal tissues may play an important role in the induction of anomalies in the corresponding tissues. |
| Databáze: | OpenAIRE |
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