20-HETE and furosemide-induced natriuresis in salt-sensitive essential hypertension
| Autor: | Cheryl L. Laffer, Mong Heng Wang, Michal Laniado-Schwartzman, Alberto Nasjletti, Fernando Elijovich |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Diuresis Natriuresis Blood Pressure Sodium Chloride Essential hypertension Plasma renin activity Urine sodium chemistry.chemical_compound Furosemide Internal medicine Renin–angiotensin system Hydroxyeicosatetraenoic Acids Renin Internal Medicine medicine Humans Aldosterone Chemistry Sodium medicine.disease Endocrinology Hypertension Female medicine.drug |
| Zdroj: | Hypertension (Dallas, Tex. : 1979). 41(3 Pt 2) |
| ISSN: | 1524-4563 |
| Popis: | Cyclooxygenase metabolites of arachidonic acid modulate the natriuretic effect of furosemide. It is not known whether 20-HETE, a monooxygenase metabolite of arachidonic acid that also inhibits sodium transport, participates in the action of furosemide. We measured urine sodium (UNaV) and 20-HETE during furosemide diuresis (40 mg three times over 12 hours) in 12 salt-sensitive (SS) and 11 salt-resistant (SR), salt-replete hypertensive subjects (126±24 mmol/24 hours positive sodium balance produced by 160-mmol-sodium diet and 2 L saline infusion). Individual systolic blood pressure decreases from the salt-replete to the salt-depleted state were the index of salt-sensitivity. SS had low plasma renin with blunted responses to changes in salt balance, inappropriate plasma aldosterone, and an increased aldosterone/renin ratio. UNaV by furosemide was less in SS (263±25 mmol/12 hours) than in SR (351±25 mmol/12 hours, P P r =0.56, P r =−0.55, P r =0.60, P r =−0.73, P |
| Databáze: | OpenAIRE |
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