Helicobacter pylori–induced matrix metallopeptidase-10 promotes gastric bacterial colonization and gastritis
| Autor: | Xiao-long Wu, Yu-gang Liu, Bin Han, Ping Cheng, Yong-sheng Teng, Yuan Zhuang, Fang-yuan Mao, Yi-pin Lv, Chuan-jie Hao, Liu-sheng Peng, Qiang Ma, Weisan Chen, Ting-ting Wang, Hui Kong, Quanming Zou, Jin-yu Zhang, Shi-Ming Yang |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
MAPK/ERK pathway
Immunology Inflammation Microbiology 03 medical and health sciences 0302 clinical medicine Immune system Gastric mucosa medicine Colonization Research Articles 030304 developmental biology 0303 health sciences Multidisciplinary biology Chemistry SciAdv r-articles Helicobacter pylori biology.organism_classification bacterial infections and mycoses digestive system diseases medicine.anatomical_structure 030211 gastroenterology & hepatology Gastritis medicine.symptom CD8 Research Article |
| Zdroj: | Science Advances |
| ISSN: | 2375-2548 |
| Popis: | Matrix metallopeptidase-10 fosters Helicobacter pylori gastric bacterial colonization and Helicobacter pylori–induced gastritis. The interaction between gastric epithelium and immune response plays key roles in H. pylori–associated pathology. We demonstrated a procolonization and proinflammation role of MMP-10 in H. pylori infection. MMP-10 is elevated in gastric mucosa and is produced by gastric epithelial cells synergistically induced by H. pylori and IL-22 via the ERK pathway. Human gastric MMP-10 was correlated with H. pylori colonization and the severity of gastritis, and mouse MMP-10 from non–BM-derived cells promoted bacteria colonization and inflammation. H. pylori colonization and inflammation were attenuated in IL-22−/−, MMP-10−/−, and IL-22−/−MMP-10−/− mice. MMP-10–associated inflammation is characterized by the influx of CD8+ T cells, whose migration is induced via MMP-10–CXCL16 axis by gastric epithelial cells. Under the influence of MMP-10, Reg3a, E-cadherin, and zonula occludens–1 proteins decrease, resulting in impaired host defense and increased H. pylori colonization. Our results suggest that MMP-10 facilitates H. pylori persistence and promotes gastritis. |
| Databáze: | OpenAIRE |
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