Immunology of Crohn's disease
| Autor: | Braat, Henri, Peppelenbosch, Maikel P., Hommes, Daan W., Domschke, WW, Kagnoff, MF, Kucharzik, TF, Mayer, LF, Targan |
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| Přispěvatelé: | Extramural researchers |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
HELPER TYPE-1 RESPONSES
NF-KAPPA-B Nod2 Signaling Adaptor Protein pattern recognition and host bacterial cells Context (language use) Disease Biology Inflammatory bowel disease DENDRITIC CELLS General Biochemistry Genetics and Molecular Biology Immune system History and Philosophy of Science Crohn Disease Immunity mucosal immunology LYMPHOID-TISSUE GALT medicine ESCHERICHIA-COLI STRAINS Humans REGULATORY T-CELLS Genetic risk Inflammation TOLL-LIKE RECEPTORS Crohn's disease CUTTING EDGE General Neuroscience Intracellular Signaling Peptides and Proteins Bacterial Infections medicine.disease Immunity Innate Mucosal immunology Immunology INTESTINAL EPITHELIAL-CELLS INFLAMMATORY-BOWEL-DISEASE |
| Zdroj: | INFLAMMATORY BOWEL DISEASE: GENETICS, BARRIER FUNCTION, IMMUNOLOGIC MECHANISMS, AND MICROBIAL PATHWAYS, 135-154 STARTPAGE=135;ENDPAGE=154;TITLE=INFLAMMATORY BOWEL DISEASE: GENETICS, BARRIER FUNCTION, IMMUNOLOGIC MECHANISMS, AND MICROBIAL PATHWAYS Annals of the New York Academy of Sciences, 1072, 135-154. Wiley-Blackwell |
| ISSN: | 0077-8923 |
| Popis: | The immense microbiological load of the gastrointestinal tract poses a daunting challenge for the mucosal immune system: whereas it should tolerate the vast number of commensal bacteria, it should adequately attack pathogenic organisms. Millions of years of co-evolution have produced an intricate system in which interactions between the endogenous flora and mucosal immune system manage to perform this difficult balancing act. When components of this interaction are defective, for instance by mutation, inflammatory bowel disease may result. In the present review, we comprehensively discuss the mucosal immune system in the context of Crohn's disease (CD) and its genetic risk factors, describe the clinical management of the disease, and discuss how knowledge of the mucosal immune system may yield novel therapeutical avenues for dealing with this debilitating disease. |
| Databáze: | OpenAIRE |
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