Studies towards the identification of potent, selective and bioavailable thrombin inhibitors

Autor:	Darryl Brynley Jones, Karen Dunnet, John Ambler, Lyndon Nigel Brown, Diana Janus, Garrick Smith, Dave Bentley, Mark Mercer, Keith Menear, Dave Farr, K D Butler, Paul Butler, Morris Tweed, Emma Baker, Mark Talbot, Darren Le Grand, Judy Hayler
Rok vydání:	1999
Předmět:	Clinical Biochemistry Biological Availability Pharmaceutical Science Biochemistry Structure-Activity Relationship Thrombin In vivo Drug Discovery medicine Potency Structure–activity relationship Molecular Biology chemistry.chemical_classification biology Organic Chemistry Anticoagulants Enzyme chemistry Enzyme inhibitor biology.protein Molecular Medicine Pharmacophore circulatory and respiratory physiology medicine.drug Discovery and development of direct thrombin inhibitors
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 9:737-742
ISSN:	0960-894X
Popis:	The application of selection criteria, based on potency and physicochemical parameters, to a candidate library of thrombin inhibitors is described. The utility of the approach is exemplified by the discovery of a potent, selective and bioavailable thrombin inhibitor 62.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b71e74af7c3708ef01cda36045d1146 https://doi.org/10.1016/s0960-894x(99)00061-x Zobrazit plný text záznamu Full Text from ScienceDirect