MicroRNAs in the pathogenesis of neuroblastoma
| Autor: | Angelika Eggert, Lukas C. Heukamp, Alexander Schramm, Reinhard Buettner, Holger Christiansen, Sebastian Horn, Johannes H. Schulte, Bernd Berwanger, Stefanie Schlierf |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Genetics
Cancer Research Small RNA Gene Expression Profiling Medizin Biology medicine.disease_cause medicine.disease law.invention Gene expression profiling MicroRNAs Neuroblastoma Oncology law microRNA medicine Cancer research Animals Humans Suppressor Epigenetics Carcinogenesis Post-transcriptional regulation |
| Popis: | MicroRNAs constitute a family of small RNA species that regulate translation and stability of mRNA. This additional layer of epigenetic regulation has escaped discovery until recently, and introduces another level between mRNA expression profiling and proteomics. Since microRNAs are involved in regulating most, if not all cellular processes, their involvement in oncogenesis was anticipated. Indeed, soon after their discovery, microRNAs were found to act as tumor suppressor genes by blocking the translation of oncogenes and act as oncogenes by inhibiting the translation of tumor suppressor genes. Here we review the most recent attempts aiming to analyze the functional roles of microRNAs in neuroblastoma, the most devastating solid tumor in childhood. |
| Databáze: | OpenAIRE |
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