A comprehensive curated resource for follicle stimulating hormone signaling
| Autor: | Akhilesh Pandey, Rajesh Raju, Aditi S. Ambekar, Sutopa B. Dwivedi, T. S. Keshava Prasad, Jagadeesha Maharudraiah, Deepthi Telikicherla, Y. L. Ramachandra, Jyoti Sharma, Subburaman Mohan, Srabani Mukherjee, Shyam Mohan Palapetta |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
endocrine system medicine.drug_class Granulosa cell Short Report lcsh:Medicine Ovary General Biochemistry Genetics and Molecular Biology Follicle-stimulating hormone Internal medicine Medicine lcsh:Science (General) Receptor lcsh:QH301-705.5 Medicine(all) Biochemistry Genetics and Molecular Biology(all) business.industry lcsh:R General Medicine Endocrinology medicine.anatomical_structure lcsh:Biology (General) Estrogen business Luteinizing hormone Follicle-stimulating hormone receptor hormones hormone substitutes and hormone antagonists lcsh:Q1-390 Hormone |
| Zdroj: | BMC Research Notes BMC Research Notes, Vol 4, Iss 1, p 408 (2011) |
| ISSN: | 1756-0500 |
| Popis: | Background Follicle stimulating hormone (FSH) is an important hormone responsible for growth, maturation and function of the human reproductive system. FSH regulates the synthesis of steroid hormones such as estrogen and progesterone, proliferation and maturation of follicles in the ovary and spermatogenesis in the testes. FSH is a glycoprotein heterodimer that binds and acts through the FSH receptor, a G-protein coupled receptor. Although online pathway repositories provide information about G-protein coupled receptor mediated signal transduction, the signaling events initiated specifically by FSH are not cataloged in any public database in a detailed fashion. Findings We performed comprehensive curation of the published literature to identify the components of FSH signaling pathway and the molecular interactions that occur upon FSH receptor activation. Our effort yielded 64 reactions comprising 35 enzyme-substrate reactions, 11 molecular association events, 11 activation events and 7 protein translocation events that occur in response to FSH receptor activation. We also cataloged 265 genes, which were differentially expressed upon FSH stimulation in normal human reproductive tissues. Conclusions We anticipate that the information provided in this resource will provide better insights into the physiological role of FSH in reproductive biology, its signaling mediators and aid in further research in this area. The curated FSH pathway data is freely available through NetPath (http://www.netpath.org), a pathway resource developed previously by our group. |
| Databáze: | OpenAIRE |
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