Stealth macromolecular platforms for the design of MRI blood pool contrast agents
| Autor: | Jean-François Desreux, Mathurin Grogna, Rudi Cloots, André Luxen, Christophe Detrembleur, Catherine Passirani, Mike Collodoro, Christine Jérôme, Nolwenn Lautram, Marie-Claire De Pauw-Gillet |
|---|---|
| Přispěvatelé: | Laboratoire de Spectroscopie d'Electrons Diffusés, Université de Liège, Laboratoire de Chimie Inorganique Structurale, Cyclotron Research Centre, Center for Education and Research on Macromolecules, Micro et Nanomédecines Biomimétiques (MINT), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL), Centre d'Etude et de Recherche sur les Macromolécules (CERM) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Gadolinium-Chelate
Polymers and Plastics Chemistry Gadolinium [SDV]Life Sciences [q-bio] Organic Chemistry chemistry.chemical_element Bioengineering Chain transfer 02 engineering and technology Raft 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Biochemistry Combinatorial chemistry Cycloaddition 0104 chemical sciences chemistry.chemical_compound Polymerization Organic chemistry Azide 0210 nano-technology Macromolecule |
| Zdroj: | Polymer Chemistry Polymer Chemistry, Royal Society of Chemistry-RSC, 2011, 2 (10), pp.2316-27. ⟨10.1039/c1py00198a⟩ |
| ISSN: | 1759-9954 1759-9962 |
| DOI: | 10.1039/c1py00198a⟩ |
| Popis: | International audience; Stealth macromolecular platforms bearing alkyne groups and poly(ethylene oxide) brushes were synthesized by reversible addition fragmentation chain transfer (RAFT) polymerization. The anchoring of Gd3+-chelates bearing an azide group was then carried out by the Huisgen 1,3-dipolar cycloaddition (“click”) reaction in mild conditions, leading to macrocontrast agents for MRI applications. The gadolinium complex is hidden in the PEO shell that renders the macrocontrast agents free of any cytotoxicity and stealth to proteins of the immune system. Relaxometry measurements have evidenced an improved relaxivity of the macrocontrast agent compared to ungrafted gadolinium chelate. Moreover, this relaxivity is further enhanced when the spacer length between the Gd3+-chelate and the polymer backbone is shorter, as the result of its decreased tumbling rate. These novel products are therefore promising candidates for MRI applications. |
| Databáze: | OpenAIRE |
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