Prognostic significance of human tissue kallikrein-related peptidases 11 and 15 in gastric cancer
Autor: | Keiyan Sy, Fabio Rotondo, Christine Brezden-Masley, Kalman Kovacs, George M. Yousef, David L. Kolin, Mena N. Bassily, Catherine J. Streutker |
---|---|
Rok vydání: | 2015 |
Předmět: |
Adult
Male 0301 basic medicine Pathology medicine.medical_specialty Stromal cell medicine.medical_treatment Adenocarcinoma Biology Young Adult 03 medical and health sciences 0302 clinical medicine Stomach Neoplasms medicine Humans Precision Medicine Lymph node Aged Proportional Hazards Models Aged 80 and over Observer Variation Tissue microarray Carcinoma Serine Endopeptidases Cancer General Medicine Kallikrein Middle Aged Prognosis medicine.disease Immunohistochemistry 030104 developmental biology medicine.anatomical_structure Tissue Array Analysis 030220 oncology & carcinogenesis Female Kallikreins Gastrectomy Cancer biomarkers |
Zdroj: | Tumor Biology. 37:437-446 |
ISSN: | 1423-0380 1010-4283 |
Popis: | Human tissue kallikrein-related peptidases (KLK) are a group of 15 serine proteases which have been investigated as potential cancer biomarkers. This study determined the prognostic significance of KLK 11 and 15 expression levels in gastric carcinoma specimens. Expression of KLK11 and KLK15 was assessed by immunohistochemistry staining on a tissue microarray constructed from 113 gastrectomy specimens from patients with gastric carcinoma. To minimize inter-observer variability, expression levels were quantified using an automated algorithm. Epithelial and stromal staining were assessed separately. Both KLK11 and KLK15 were expressed in gastric carcinoma. There was no significant correlation between either KLK11 or KLK15 expression and the presence of lymph node metastases or Lauren classification (intestinal vs. diffuse). Higher levels of KLK11 expression in gastric carcinoma were associated with significantly worse overall survival (p = 0.008), and a multivariate analysis showed that it had prognostic value independent of tumor stage and differentiation (p = 0.004). Variations in KLK15 expression were not significantly associated with prognosis. KLK11 shows promise as a potential independent prognostic marker for gastric carcinoma. |
Databáze: | OpenAIRE |
Externí odkaz: |