Design rules for a tunable merged-tip microneedle
Autor: | Dal-Hee Min, Jungeun Lim, Noo Li Jeon, James Yu, Dongha Tahk |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Materials science Fabrication Materials Science (miscellaneous) Nanotechnology 02 engineering and technology Volume control lcsh:Technology Industrial and Manufacturing Engineering law.invention 03 medical and health sciences law Electrical and Electronic Engineering Microscale chemistry chemistry.chemical_classification business.industry lcsh:T technology industry and agriculture Polymer Modular design 021001 nanoscience & nanotechnology Condensed Matter Physics Biocompatible material Atomic and Molecular Physics and Optics Surface micromachining 030104 developmental biology chemistry lcsh:TA1-2040 Photolithography 0210 nano-technology business lcsh:Engineering (General). Civil engineering (General) |
Zdroj: | Microsystems & Nanoengineering, Vol 4, Iss 1, Pp 1-10 (2018) |
ISSN: | 2055-7434 |
Popis: | This publication proposes the use of an elasto-capillarity-driven self-assembly for fabricating a microscale merged-tip structure out of a variety of biocompatible UV-curable polymers for use as a microneedle platform. In addition, the novel merged-tip microstructure constitutes a new class of microneedles, which incorporates the convergence of biocompatible polymer micropillars, leading to the formation of a sharp tip and an open cavity capable of both liquid trapping and volume control. When combined with biocompatible photopolymer micropillar arrays fabricated with photolithography, elasto-capillarity-driven self-assembly provides a means for producing a complex microneedle-like structure without the use of micromolding or micromachining. This publication also explores and defines the design rules by which several fabrication aspects, such as micropillar dimensions, shapes, pattern array configurations, and materials, can be manipulated to produce a customizable microneedle array with controllable cavity volumes, fracture points, and merge profiles. In addition, the incorporation of a modular through-hole micropore membrane base was also investigated as a method for constitutive payload delivery and fluid-sampling functionalities. The flexibility and fabrication simplicity of the merged-tip microneedle platform holds promise in transdermal drug delivery applications. |
Databáze: | OpenAIRE |
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